High-Definition and 3-dimensional Imaging of Macular Pathologies with High-speed Ultrahigh-Resolution Optical Coherence Tomography

Vivek Srinivasan, Maciej Wojtkowski, Andre J. Witkin, Jay S. Duker, Tony H. Ko, Mariana Carvalho, Joel S. Schuman, Andrzej Kowalczyk, James G. Fujimoto

Research output: Contribution to journalArticle

246 Citations (Scopus)

Abstract

Objective: To assess high-speed ultrahigh-resolution optical coherence tomography (OCT) image resolution, acquisition speed, image quality, and retinal coverage for the visualization of macular pathologies. Design: Retrospective cross-sectional study. Participants: Five hundred eighty-eight eyes of 327 patients with various macular pathologies. Methods: High-speed ultrahigh-resolution OCT images were obtained in 588 eyes of 327 patients with selected macular diseases. Ultrahigh-resolution OCT using Fourier/spectral domain detection achieves ∼3-μm axial image resolutions, acquisition speeds of ∼25 000 axial scans per second, and >3 times finer resolution and >50 times higher speed than standard OCT. Three scan protocols were investigated. The first acquires a small number of high-definition images through the fovea. The second acquires a raster series of high-transverse pixel density images. The third acquires 3-dimensional OCT data using a dense raster pattern. Three-dimensional OCT can generate OCT fundus images that enable precise registration of OCT images with the fundus. Using the OCT fundus images, OCT results were correlated with standard ophthalmoscopic examination techniques. Main Outcome Measures: High-definition macular pathologies. Results: Macular holes, age-related macular degeneration, epiretinal membranes, diabetic retinopathy, retinal dystrophies, central serous chorioretinopathy, and other pathologies were imaged and correlated with ophthalmic examination, standard OCT, fundus photography, and fluorescein angiography, where applicable. High-speed ultrahigh-resolution OCT generates images of retinal pathologies with improved quality, more comprehensive retinal coverage, and more precise registration than standard OCT. The speed preserves retinal topography, thus enabling the visualization of subtle changes associated with disease. High-definition high-transverse pixel density OCT images improve visualization of photoreceptor and pigment epithelial morphology, as well as thin intraretinal and epiretinal structures. Three-dimensional OCT enables comprehensive retinal coverage, reduces sampling errors, and enables assessment of 3-dimensional pathology. Conclusions: High-definition 3-dimensional imaging using high-speed ultrahigh-resolution OCT improves image quality, retinal coverage, and registration. This new technology has the potential to become a useful tool for elucidating disease pathogenesis and improving disease diagnosis and management.

Original languageEnglish (US)
JournalOphthalmology
Volume113
Issue number11
DOIs
StatePublished - Nov 1 2006
Externally publishedYes

Fingerprint

Optical Coherence Tomography
Pathology
Retinal Dystrophies
Central Serous Chorioretinopathy
Epiretinal Membrane
Retinal Perforations
Selection Bias
Fluorescein Angiography
Photography
Macular Degeneration
Diabetic Retinopathy
Disease Management

ASJC Scopus subject areas

  • Ophthalmology

Cite this

High-Definition and 3-dimensional Imaging of Macular Pathologies with High-speed Ultrahigh-Resolution Optical Coherence Tomography. / Srinivasan, Vivek; Wojtkowski, Maciej; Witkin, Andre J.; Duker, Jay S.; Ko, Tony H.; Carvalho, Mariana; Schuman, Joel S.; Kowalczyk, Andrzej; Fujimoto, James G.

In: Ophthalmology, Vol. 113, No. 11, 01.11.2006.

Research output: Contribution to journalArticle

Srinivasan, Vivek ; Wojtkowski, Maciej ; Witkin, Andre J. ; Duker, Jay S. ; Ko, Tony H. ; Carvalho, Mariana ; Schuman, Joel S. ; Kowalczyk, Andrzej ; Fujimoto, James G. / High-Definition and 3-dimensional Imaging of Macular Pathologies with High-speed Ultrahigh-Resolution Optical Coherence Tomography. In: Ophthalmology. 2006 ; Vol. 113, No. 11.
@article{b48bfe2229e9454ca10c2a9530673f95,
title = "High-Definition and 3-dimensional Imaging of Macular Pathologies with High-speed Ultrahigh-Resolution Optical Coherence Tomography",
abstract = "Objective: To assess high-speed ultrahigh-resolution optical coherence tomography (OCT) image resolution, acquisition speed, image quality, and retinal coverage for the visualization of macular pathologies. Design: Retrospective cross-sectional study. Participants: Five hundred eighty-eight eyes of 327 patients with various macular pathologies. Methods: High-speed ultrahigh-resolution OCT images were obtained in 588 eyes of 327 patients with selected macular diseases. Ultrahigh-resolution OCT using Fourier/spectral domain detection achieves ∼3-μm axial image resolutions, acquisition speeds of ∼25 000 axial scans per second, and >3 times finer resolution and >50 times higher speed than standard OCT. Three scan protocols were investigated. The first acquires a small number of high-definition images through the fovea. The second acquires a raster series of high-transverse pixel density images. The third acquires 3-dimensional OCT data using a dense raster pattern. Three-dimensional OCT can generate OCT fundus images that enable precise registration of OCT images with the fundus. Using the OCT fundus images, OCT results were correlated with standard ophthalmoscopic examination techniques. Main Outcome Measures: High-definition macular pathologies. Results: Macular holes, age-related macular degeneration, epiretinal membranes, diabetic retinopathy, retinal dystrophies, central serous chorioretinopathy, and other pathologies were imaged and correlated with ophthalmic examination, standard OCT, fundus photography, and fluorescein angiography, where applicable. High-speed ultrahigh-resolution OCT generates images of retinal pathologies with improved quality, more comprehensive retinal coverage, and more precise registration than standard OCT. The speed preserves retinal topography, thus enabling the visualization of subtle changes associated with disease. High-definition high-transverse pixel density OCT images improve visualization of photoreceptor and pigment epithelial morphology, as well as thin intraretinal and epiretinal structures. Three-dimensional OCT enables comprehensive retinal coverage, reduces sampling errors, and enables assessment of 3-dimensional pathology. Conclusions: High-definition 3-dimensional imaging using high-speed ultrahigh-resolution OCT improves image quality, retinal coverage, and registration. This new technology has the potential to become a useful tool for elucidating disease pathogenesis and improving disease diagnosis and management.",
author = "Vivek Srinivasan and Maciej Wojtkowski and Witkin, {Andre J.} and Duker, {Jay S.} and Ko, {Tony H.} and Mariana Carvalho and Schuman, {Joel S.} and Andrzej Kowalczyk and Fujimoto, {James G.}",
year = "2006",
month = "11",
day = "1",
doi = "10.1016/j.ophtha.2006.05.046",
language = "English (US)",
volume = "113",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "11",

}

TY - JOUR

T1 - High-Definition and 3-dimensional Imaging of Macular Pathologies with High-speed Ultrahigh-Resolution Optical Coherence Tomography

AU - Srinivasan, Vivek

AU - Wojtkowski, Maciej

AU - Witkin, Andre J.

AU - Duker, Jay S.

AU - Ko, Tony H.

AU - Carvalho, Mariana

AU - Schuman, Joel S.

AU - Kowalczyk, Andrzej

AU - Fujimoto, James G.

PY - 2006/11/1

Y1 - 2006/11/1

N2 - Objective: To assess high-speed ultrahigh-resolution optical coherence tomography (OCT) image resolution, acquisition speed, image quality, and retinal coverage for the visualization of macular pathologies. Design: Retrospective cross-sectional study. Participants: Five hundred eighty-eight eyes of 327 patients with various macular pathologies. Methods: High-speed ultrahigh-resolution OCT images were obtained in 588 eyes of 327 patients with selected macular diseases. Ultrahigh-resolution OCT using Fourier/spectral domain detection achieves ∼3-μm axial image resolutions, acquisition speeds of ∼25 000 axial scans per second, and >3 times finer resolution and >50 times higher speed than standard OCT. Three scan protocols were investigated. The first acquires a small number of high-definition images through the fovea. The second acquires a raster series of high-transverse pixel density images. The third acquires 3-dimensional OCT data using a dense raster pattern. Three-dimensional OCT can generate OCT fundus images that enable precise registration of OCT images with the fundus. Using the OCT fundus images, OCT results were correlated with standard ophthalmoscopic examination techniques. Main Outcome Measures: High-definition macular pathologies. Results: Macular holes, age-related macular degeneration, epiretinal membranes, diabetic retinopathy, retinal dystrophies, central serous chorioretinopathy, and other pathologies were imaged and correlated with ophthalmic examination, standard OCT, fundus photography, and fluorescein angiography, where applicable. High-speed ultrahigh-resolution OCT generates images of retinal pathologies with improved quality, more comprehensive retinal coverage, and more precise registration than standard OCT. The speed preserves retinal topography, thus enabling the visualization of subtle changes associated with disease. High-definition high-transverse pixel density OCT images improve visualization of photoreceptor and pigment epithelial morphology, as well as thin intraretinal and epiretinal structures. Three-dimensional OCT enables comprehensive retinal coverage, reduces sampling errors, and enables assessment of 3-dimensional pathology. Conclusions: High-definition 3-dimensional imaging using high-speed ultrahigh-resolution OCT improves image quality, retinal coverage, and registration. This new technology has the potential to become a useful tool for elucidating disease pathogenesis and improving disease diagnosis and management.

AB - Objective: To assess high-speed ultrahigh-resolution optical coherence tomography (OCT) image resolution, acquisition speed, image quality, and retinal coverage for the visualization of macular pathologies. Design: Retrospective cross-sectional study. Participants: Five hundred eighty-eight eyes of 327 patients with various macular pathologies. Methods: High-speed ultrahigh-resolution OCT images were obtained in 588 eyes of 327 patients with selected macular diseases. Ultrahigh-resolution OCT using Fourier/spectral domain detection achieves ∼3-μm axial image resolutions, acquisition speeds of ∼25 000 axial scans per second, and >3 times finer resolution and >50 times higher speed than standard OCT. Three scan protocols were investigated. The first acquires a small number of high-definition images through the fovea. The second acquires a raster series of high-transverse pixel density images. The third acquires 3-dimensional OCT data using a dense raster pattern. Three-dimensional OCT can generate OCT fundus images that enable precise registration of OCT images with the fundus. Using the OCT fundus images, OCT results were correlated with standard ophthalmoscopic examination techniques. Main Outcome Measures: High-definition macular pathologies. Results: Macular holes, age-related macular degeneration, epiretinal membranes, diabetic retinopathy, retinal dystrophies, central serous chorioretinopathy, and other pathologies were imaged and correlated with ophthalmic examination, standard OCT, fundus photography, and fluorescein angiography, where applicable. High-speed ultrahigh-resolution OCT generates images of retinal pathologies with improved quality, more comprehensive retinal coverage, and more precise registration than standard OCT. The speed preserves retinal topography, thus enabling the visualization of subtle changes associated with disease. High-definition high-transverse pixel density OCT images improve visualization of photoreceptor and pigment epithelial morphology, as well as thin intraretinal and epiretinal structures. Three-dimensional OCT enables comprehensive retinal coverage, reduces sampling errors, and enables assessment of 3-dimensional pathology. Conclusions: High-definition 3-dimensional imaging using high-speed ultrahigh-resolution OCT improves image quality, retinal coverage, and registration. This new technology has the potential to become a useful tool for elucidating disease pathogenesis and improving disease diagnosis and management.

UR - http://www.scopus.com/inward/record.url?scp=33750285060&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750285060&partnerID=8YFLogxK

U2 - 10.1016/j.ophtha.2006.05.046

DO - 10.1016/j.ophtha.2006.05.046

M3 - Article

C2 - 17074565

AN - SCOPUS:33750285060

VL - 113

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 11

ER -