HIF1 and oxygen sensing in the brain

Frank R Sharp, Myriam Bernaudin

Research output: Contribution to journalArticle

381 Scopus citations

Abstract

Of all the chemical elements, oxygen is the most vital to the human body. The brain is the most sensitive organ to oxygen deprivation (hypoxia), which, over an extended period, can cause coma, seizures, cognitive impairment and other neurological disabilities, and even brain death. However, during mild hypoxia of short duration, the brain develops adaptative mechanisms that allow it to maintain normal physiological conditions. In this review, we discuss some of the molecular mechanisms of oxygen sensing in the brain. Particular emphasis is placed on the oxygen-dependant regulation of the transcription factor HIF1 (hypoxia-inducible factor 1) - one of the main cellular responses to hypoxia that operates in numerous cell types.

Original languageEnglish (US)
Pages (from-to)437-448
Number of pages12
JournalNature Reviews Neuroscience
Volume5
Issue number6
StatePublished - Jun 2004

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cell Biology

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