Hibernation: The search for treatments to prevent disuse-induced skeletal muscle atrophy

Sue C. Bodine

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Loss of skeletal muscle mass is a serious consequence of multiple diseases and conditions for which there is limited treatment options. Disuse-induced muscle atrophy occurs as the result of both reduced mechanical loading and decreased neural activity. Hibernation represents a unique physiological state where skeletal muscles are protected from unloading, inactivity and nutritional deprivation. A recent study published in Experimental Neurology Xu et al., 2013) utilized the thirteen-lined ground squirrel, a natural hibernator, to specifically examine whether peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1-a (PGC-1a) and its associated upstream and downstream signaling partners were increased during hibernation. The results showed an increase in PGC-1a expression as well as increases in mitochondrial biogenesis, oxidative capacity, and antioxidant capacity in hibernating animals. It was suggested that upregulation of PCG-1a could be a viable strategy for the treatment of disuse-induced atrophy in humans. This commentary discusses the results of Xu et al. in the context of other studies that have examined muscle sparing in hibernating mammals, and compares these findings to what is known about disuse-induced atrophy in nonhibernating rodents and humans.

Original languageEnglish (US)
Pages (from-to)129-135
Number of pages7
JournalExperimental Neurology
StatePublished - Oct 2013

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience


Dive into the research topics of 'Hibernation: The search for treatments to prevent disuse-induced skeletal muscle atrophy'. Together they form a unique fingerprint.

Cite this