Heteromerization of TRP channel subunits: Extending functional diversity

Wei Cheng, Changsen Sun, Jie Zheng

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Transient receptor potential (TRP) channels are widely found throughout the animal kingdom. By serving as cellular sensors for a wide spectrum of physical and chemical stimuli, they play crucial physiological roles ranging from sensory transduction to cell cycle modulation. TRP channels are tetrameric protein complexes. While most TRP subunits can form functional homomeric channels, heteromerization of TRP channel subunits of either the same subfamily or different subfamilies has been widely observed. Heteromeric TRP channels exhibit many novel properties compared to their homomeric counterparts, indicating that co-assembly of TRP channel subunits has an important contribution to the diversity of TRP channel functions.

Original languageEnglish (US)
Pages (from-to)802-810
Number of pages9
JournalProtein and Cell
Volume1
Issue number9
DOIs
StatePublished - 2010

Keywords

  • co-assembly
  • diversification
  • molecular mechanism
  • multi-subunit protein complex
  • nonselective cation channel
  • polymodal receptor

ASJC Scopus subject areas

  • Biotechnology
  • Cell Biology
  • Drug Discovery
  • Biochemistry

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