Heterologous passive cutaneous anaphylaxis with bovine immunoglobulin E.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Immunoglobulin (Ig) E was detected in sera of cows previously inoculated with ovalbumin in alum or in Freund's incomplete adjuvant. Titers greater than 64 were produced by homologous passive cutaneous anaphylaxis (PCA) reactions on calf skin, using sera from these cows. This bovine IgE was heat labile. Bovine sera containing IgE were used to examine cross-species reactivity by heterologous PCA. Rats, rabbits, guinea pigs, and dogs failed to develop PCA reactions when sensitized by intradermal injections of the bovine IgE and challenge exposed at intervals from 2 to 72 hours later with IV ovalbumin and Evan's blue dye. In contrast, sheep and goats became passively sensitized by the bovine IgE. Considerable variation in latent period and titer was apparent after comparison of results in heterologous species with each other and with the homologous recipient. Nonetheless, the ability of this homocytotropic antibody to cross species is important to the phylogenetic relationship of IgE in different species.

Original languageEnglish (US)
Pages (from-to)1184-1187
Number of pages4
JournalAmerican Journal of Veterinary Research
Volume42
Issue number7
StatePublished - Jul 1981

Fingerprint

immunoglobulin E
anaphylaxis
Passive Cutaneous Anaphylaxis
Immunoglobulin E
cattle
ovalbumin
cows
latent period
alum
Serum
skin (animal)
guinea pigs
adjuvants
dyes
Intradermal Injections
Evans Blue
goats
rabbits
Ovalbumin
calves

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Heterologous passive cutaneous anaphylaxis with bovine immunoglobulin E. / Gershwin, L. J.

In: American Journal of Veterinary Research, Vol. 42, No. 7, 07.1981, p. 1184-1187.

Research output: Contribution to journalArticle

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