Heterogeneity of the psychoses: Is there a neurodegenerative psychosis?

James L. Knoll IV, David L. Garver, Jane E. Ramberg, Steven J. Kingsbury, Deborah Croissant, Barbara E McDermott

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Whereas etiological heterogeneity of the various types of schizophrenia has been repeatedly proposed, relatively few attempts have been made to separate the component diseases. Using a strategy focusing on bimodal distributions within several relevant domains of schizophrenia, we demonstrate that currently available data on schizophrenia patients are consistent with the hypothesis that some of these patients have an ongoing neurodegenerative disease, whereas others do not. We review studies (longitudinal and cross-sectional) documenting progressive increases in ventricular size, accelerated loss of brain tissues, progressive delays in treatment response, and neurochemical (magnetic resonance spectroscopy) and neurophysiological (P300) indices, all of which are consistent with ongoing cerebral degeneration in a significant subgroup of schizophrenia patients. These lines of evidence converge on a conceptualization of schizophrenia as being composed of several etiologically distinct processes, with one subset of psychotic patients evidencing progressive brain degeneration. We conclude with a discussion of possible etiologies for this condition.

Original languageEnglish (US)
Pages (from-to)365-379
Number of pages15
JournalSchizophrenia Bulletin
Volume24
Issue number3
StatePublished - 1998
Externally publishedYes

Fingerprint

Psychotic Disorders
Schizophrenia
Brain
Neurodegenerative Diseases
Magnetic Resonance Spectroscopy
Cross-Sectional Studies
Therapeutics

Keywords

  • Apoptosis
  • Degeneration
  • Drug response
  • Evoked cortical response
  • Heterogeneity
  • Phosphoesters
  • Ventricular brain ratio

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Knoll IV, J. L., Garver, D. L., Ramberg, J. E., Kingsbury, S. J., Croissant, D., & McDermott, B. E. (1998). Heterogeneity of the psychoses: Is there a neurodegenerative psychosis? Schizophrenia Bulletin, 24(3), 365-379.

Heterogeneity of the psychoses : Is there a neurodegenerative psychosis? / Knoll IV, James L.; Garver, David L.; Ramberg, Jane E.; Kingsbury, Steven J.; Croissant, Deborah; McDermott, Barbara E.

In: Schizophrenia Bulletin, Vol. 24, No. 3, 1998, p. 365-379.

Research output: Contribution to journalArticle

Knoll IV, JL, Garver, DL, Ramberg, JE, Kingsbury, SJ, Croissant, D & McDermott, BE 1998, 'Heterogeneity of the psychoses: Is there a neurodegenerative psychosis?', Schizophrenia Bulletin, vol. 24, no. 3, pp. 365-379.
Knoll IV JL, Garver DL, Ramberg JE, Kingsbury SJ, Croissant D, McDermott BE. Heterogeneity of the psychoses: Is there a neurodegenerative psychosis? Schizophrenia Bulletin. 1998;24(3):365-379.
Knoll IV, James L. ; Garver, David L. ; Ramberg, Jane E. ; Kingsbury, Steven J. ; Croissant, Deborah ; McDermott, Barbara E. / Heterogeneity of the psychoses : Is there a neurodegenerative psychosis?. In: Schizophrenia Bulletin. 1998 ; Vol. 24, No. 3. pp. 365-379.
@article{9edab91c4fc7450783010d2f8767ce12,
title = "Heterogeneity of the psychoses: Is there a neurodegenerative psychosis?",
abstract = "Whereas etiological heterogeneity of the various types of schizophrenia has been repeatedly proposed, relatively few attempts have been made to separate the component diseases. Using a strategy focusing on bimodal distributions within several relevant domains of schizophrenia, we demonstrate that currently available data on schizophrenia patients are consistent with the hypothesis that some of these patients have an ongoing neurodegenerative disease, whereas others do not. We review studies (longitudinal and cross-sectional) documenting progressive increases in ventricular size, accelerated loss of brain tissues, progressive delays in treatment response, and neurochemical (magnetic resonance spectroscopy) and neurophysiological (P300) indices, all of which are consistent with ongoing cerebral degeneration in a significant subgroup of schizophrenia patients. These lines of evidence converge on a conceptualization of schizophrenia as being composed of several etiologically distinct processes, with one subset of psychotic patients evidencing progressive brain degeneration. We conclude with a discussion of possible etiologies for this condition.",
keywords = "Apoptosis, Degeneration, Drug response, Evoked cortical response, Heterogeneity, Phosphoesters, Ventricular brain ratio",
author = "{Knoll IV}, {James L.} and Garver, {David L.} and Ramberg, {Jane E.} and Kingsbury, {Steven J.} and Deborah Croissant and McDermott, {Barbara E}",
year = "1998",
language = "English (US)",
volume = "24",
pages = "365--379",
journal = "Schizophrenia Bulletin",
issn = "0586-7614",
publisher = "Oxford University Press",
number = "3",

}

TY - JOUR

T1 - Heterogeneity of the psychoses

T2 - Is there a neurodegenerative psychosis?

AU - Knoll IV, James L.

AU - Garver, David L.

AU - Ramberg, Jane E.

AU - Kingsbury, Steven J.

AU - Croissant, Deborah

AU - McDermott, Barbara E

PY - 1998

Y1 - 1998

N2 - Whereas etiological heterogeneity of the various types of schizophrenia has been repeatedly proposed, relatively few attempts have been made to separate the component diseases. Using a strategy focusing on bimodal distributions within several relevant domains of schizophrenia, we demonstrate that currently available data on schizophrenia patients are consistent with the hypothesis that some of these patients have an ongoing neurodegenerative disease, whereas others do not. We review studies (longitudinal and cross-sectional) documenting progressive increases in ventricular size, accelerated loss of brain tissues, progressive delays in treatment response, and neurochemical (magnetic resonance spectroscopy) and neurophysiological (P300) indices, all of which are consistent with ongoing cerebral degeneration in a significant subgroup of schizophrenia patients. These lines of evidence converge on a conceptualization of schizophrenia as being composed of several etiologically distinct processes, with one subset of psychotic patients evidencing progressive brain degeneration. We conclude with a discussion of possible etiologies for this condition.

AB - Whereas etiological heterogeneity of the various types of schizophrenia has been repeatedly proposed, relatively few attempts have been made to separate the component diseases. Using a strategy focusing on bimodal distributions within several relevant domains of schizophrenia, we demonstrate that currently available data on schizophrenia patients are consistent with the hypothesis that some of these patients have an ongoing neurodegenerative disease, whereas others do not. We review studies (longitudinal and cross-sectional) documenting progressive increases in ventricular size, accelerated loss of brain tissues, progressive delays in treatment response, and neurochemical (magnetic resonance spectroscopy) and neurophysiological (P300) indices, all of which are consistent with ongoing cerebral degeneration in a significant subgroup of schizophrenia patients. These lines of evidence converge on a conceptualization of schizophrenia as being composed of several etiologically distinct processes, with one subset of psychotic patients evidencing progressive brain degeneration. We conclude with a discussion of possible etiologies for this condition.

KW - Apoptosis

KW - Degeneration

KW - Drug response

KW - Evoked cortical response

KW - Heterogeneity

KW - Phosphoesters

KW - Ventricular brain ratio

UR - http://www.scopus.com/inward/record.url?scp=0031846259&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031846259&partnerID=8YFLogxK

M3 - Article

C2 - 9718629

AN - SCOPUS:0031846259

VL - 24

SP - 365

EP - 379

JO - Schizophrenia Bulletin

JF - Schizophrenia Bulletin

SN - 0586-7614

IS - 3

ER -