hESC-derived hepatocytes

Iman Saramipoor Behbahan, Mark A Zern

Research output: Chapter in Book/Report/Conference proceedingChapter


Liver transplantation is the most effective treatment for end-stage liver diseases. However, shortage of donor livers has limited its clinical application. Transfusion of primary hepatocyte from cadaveric livers is a potential effective alternative. Since donor livers are scarce, and adult hepatocytes cannot be expanded in culture, hepatocyte transplantation has not become a viable substitute to whole organ transplantation. Since hESCs replicate virtually indefinitely in culture, an infinite source of hepatocytes will therefore be available for therapeutics and for toxicology and pharmacology studies. This review will provide scientists and physicians with the latest achievements in the rapidly growing field of embryonic stem cell biology as it pertains to liver cell differentiation.

Original languageEnglish (US)
Title of host publicationAdvances in Stem Cell Research
PublisherHumana Press Inc.
Number of pages18
ISBN (Electronic)9781617799402
ISBN (Print)9781617799396
StatePublished - Jan 1 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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