hESC-derived hepatocytes

Iman Saramipoor Behbahan, Mark A Zern

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Liver transplantation is the most effective treatment for end-stage liver diseases. However, shortage of donor livers has limited its clinical application. Transfusion of primary hepatocyte from cadaveric livers is a potential effective alternative. Since donor livers are scarce, and adult hepatocytes cannot be expanded in culture, hepatocyte transplantation has not become a viable substitute to whole organ transplantation. Since hESCs replicate virtually indefinitely in culture, an infinite source of hepatocytes will therefore be available for therapeutics and for toxicology and pharmacology studies. This review will provide scientists and physicians with the latest achievements in the rapidly growing field of embryonic stem cell biology as it pertains to liver cell differentiation.

Original languageEnglish (US)
Title of host publicationAdvances in Stem Cell Research
PublisherHumana Press Inc.
Pages49-66
Number of pages18
ISBN (Electronic)9781617799402
ISBN (Print)9781617799396
DOIs
StatePublished - Jan 1 2012

Fingerprint

Liver
Hepatocytes
Tissue Donors
End Stage Liver Disease
Organ Transplantation
Embryonic Stem Cells
Cytology
Liver Transplantation
Toxicology
Transplantation (surgical)
Cell Biology
Cell Differentiation
Transplantation
Pharmacology
Stem cells
Physicians
Human Embryonic Stem Cells
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Behbahan, I. S., & Zern, M. A. (2012). hESC-derived hepatocytes. In Advances in Stem Cell Research (pp. 49-66). Humana Press Inc.. https://doi.org/10.1007/978-1-61779-940-2_4

hESC-derived hepatocytes. / Behbahan, Iman Saramipoor; Zern, Mark A.

Advances in Stem Cell Research. Humana Press Inc., 2012. p. 49-66.

Research output: Chapter in Book/Report/Conference proceedingChapter

Behbahan, IS & Zern, MA 2012, hESC-derived hepatocytes. in Advances in Stem Cell Research. Humana Press Inc., pp. 49-66. https://doi.org/10.1007/978-1-61779-940-2_4
Behbahan IS, Zern MA. hESC-derived hepatocytes. In Advances in Stem Cell Research. Humana Press Inc. 2012. p. 49-66 https://doi.org/10.1007/978-1-61779-940-2_4
Behbahan, Iman Saramipoor ; Zern, Mark A. / hESC-derived hepatocytes. Advances in Stem Cell Research. Humana Press Inc., 2012. pp. 49-66
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