Abstract
Liver transplantation is the most effective treatment for end-stage liver diseases. However, shortage of donor livers has limited its clinical application. Transfusion of primary hepatocyte from cadaveric livers is a potential effective alternative. Since donor livers are scarce, and adult hepatocytes cannot be expanded in culture, hepatocyte transplantation has not become a viable substitute to whole organ transplantation. Since hESCs replicate virtually indefinitely in culture, an infinite source of hepatocytes will therefore be available for therapeutics and for toxicology and pharmacology studies. This review will provide scientists and physicians with the latest achievements in the rapidly growing field of embryonic stem cell biology as it pertains to liver cell differentiation.
| Original language | English (US) |
|---|---|
| Title of host publication | Advances in Stem Cell Research |
| Publisher | Humana Press Inc. |
| Pages | 49-66 |
| Number of pages | 18 |
| ISBN (Electronic) | 9781617799402 |
| ISBN (Print) | 9781617799396 |
| DOIs | |
| State | Published - Jan 1 2012 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
hESC-derived hepatocytes. / Behbahan, Iman Saramipoor; Zern, Mark A.
Advances in Stem Cell Research. Humana Press Inc., 2012. p. 49-66.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - hESC-derived hepatocytes
AU - Behbahan, Iman Saramipoor
AU - Zern, Mark A
PY - 2012/1/1
Y1 - 2012/1/1
N2 - Liver transplantation is the most effective treatment for end-stage liver diseases. However, shortage of donor livers has limited its clinical application. Transfusion of primary hepatocyte from cadaveric livers is a potential effective alternative. Since donor livers are scarce, and adult hepatocytes cannot be expanded in culture, hepatocyte transplantation has not become a viable substitute to whole organ transplantation. Since hESCs replicate virtually indefinitely in culture, an infinite source of hepatocytes will therefore be available for therapeutics and for toxicology and pharmacology studies. This review will provide scientists and physicians with the latest achievements in the rapidly growing field of embryonic stem cell biology as it pertains to liver cell differentiation.
AB - Liver transplantation is the most effective treatment for end-stage liver diseases. However, shortage of donor livers has limited its clinical application. Transfusion of primary hepatocyte from cadaveric livers is a potential effective alternative. Since donor livers are scarce, and adult hepatocytes cannot be expanded in culture, hepatocyte transplantation has not become a viable substitute to whole organ transplantation. Since hESCs replicate virtually indefinitely in culture, an infinite source of hepatocytes will therefore be available for therapeutics and for toxicology and pharmacology studies. This review will provide scientists and physicians with the latest achievements in the rapidly growing field of embryonic stem cell biology as it pertains to liver cell differentiation.
UR - http://www.scopus.com/inward/record.url?scp=85026474114&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85026474114&partnerID=8YFLogxK
U2 - 10.1007/978-1-61779-940-2_4
DO - 10.1007/978-1-61779-940-2_4
M3 - Chapter
AN - SCOPUS:85026474114
SN - 9781617799396
SP - 49
EP - 66
BT - Advances in Stem Cell Research
PB - Humana Press Inc.
ER -