Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor

Zhengbin Yao, William C. Fanslow, Michael F Seldin, Anne Marie Rousseau, Sally L. Painter, Michael R. Comeau, Jeffrey I. Cohen, Melanie K. Spriggs

Research output: Contribution to journalArticle

713 Citations (Scopus)

Abstract

Herpesvirus Saimiri gene 13 (HVS13) exhibits 57% identity with the predicted sequence of a T cell-derived molecule termed CTLAB. Recombinant HVS13 and CTLA8 stimulate transcriptional factor NF-κB activity and Interleukin-6 (IL-6) secretion in fibroblasts, and costimulate T cell proliferation. An HVS13.Fc fusion protein was used to isolate a cl)NA encoding a novel receptor that also binds CTLA8. This receptor is unrelated to previously Identified cytokine receptor families. A recombinant soluble receptor inhibited T cell proliferation and IL-2 production Induced by PHA, concanavalin A (conA), and anti-TCR MAb. These results define CTLA8 and HVS13 as novel cytokines that bind to a novel cytokine receptor. We propose to call these molecules IL-17, vIL-17, and IL-17R, respectively.

Original languageEnglish (US)
Pages (from-to)811-821
Number of pages11
JournalImmunity
Volume3
Issue number6
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Saimiriine Herpesvirus 2
Cytokine Receptors
Interleukin-17
Cytokines
Genes
Cell Proliferation
T-Lymphocytes
Concanavalin A
Interleukin-2
Interleukin-6
Fibroblasts
Proteins

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Infectious Diseases

Cite this

Yao, Z., Fanslow, W. C., Seldin, M. F., Rousseau, A. M., Painter, S. L., Comeau, M. R., ... Spriggs, M. K. (1995). Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity, 3(6), 811-821. https://doi.org/10.1016/1074-7613(95)90070-5

Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. / Yao, Zhengbin; Fanslow, William C.; Seldin, Michael F; Rousseau, Anne Marie; Painter, Sally L.; Comeau, Michael R.; Cohen, Jeffrey I.; Spriggs, Melanie K.

In: Immunity, Vol. 3, No. 6, 1995, p. 811-821.

Research output: Contribution to journalArticle

Yao, Z, Fanslow, WC, Seldin, MF, Rousseau, AM, Painter, SL, Comeau, MR, Cohen, JI & Spriggs, MK 1995, 'Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor', Immunity, vol. 3, no. 6, pp. 811-821. https://doi.org/10.1016/1074-7613(95)90070-5
Yao, Zhengbin ; Fanslow, William C. ; Seldin, Michael F ; Rousseau, Anne Marie ; Painter, Sally L. ; Comeau, Michael R. ; Cohen, Jeffrey I. ; Spriggs, Melanie K. / Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. In: Immunity. 1995 ; Vol. 3, No. 6. pp. 811-821.
@article{74673822711f4b2981035b5861eb8cbb,
title = "Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor",
abstract = "Herpesvirus Saimiri gene 13 (HVS13) exhibits 57{\%} identity with the predicted sequence of a T cell-derived molecule termed CTLAB. Recombinant HVS13 and CTLA8 stimulate transcriptional factor NF-κB activity and Interleukin-6 (IL-6) secretion in fibroblasts, and costimulate T cell proliferation. An HVS13.Fc fusion protein was used to isolate a cl)NA encoding a novel receptor that also binds CTLA8. This receptor is unrelated to previously Identified cytokine receptor families. A recombinant soluble receptor inhibited T cell proliferation and IL-2 production Induced by PHA, concanavalin A (conA), and anti-TCR MAb. These results define CTLA8 and HVS13 as novel cytokines that bind to a novel cytokine receptor. We propose to call these molecules IL-17, vIL-17, and IL-17R, respectively.",
author = "Zhengbin Yao and Fanslow, {William C.} and Seldin, {Michael F} and Rousseau, {Anne Marie} and Painter, {Sally L.} and Comeau, {Michael R.} and Cohen, {Jeffrey I.} and Spriggs, {Melanie K.}",
year = "1995",
doi = "10.1016/1074-7613(95)90070-5",
language = "English (US)",
volume = "3",
pages = "811--821",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "6",

}

TY - JOUR

T1 - Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor

AU - Yao, Zhengbin

AU - Fanslow, William C.

AU - Seldin, Michael F

AU - Rousseau, Anne Marie

AU - Painter, Sally L.

AU - Comeau, Michael R.

AU - Cohen, Jeffrey I.

AU - Spriggs, Melanie K.

PY - 1995

Y1 - 1995

N2 - Herpesvirus Saimiri gene 13 (HVS13) exhibits 57% identity with the predicted sequence of a T cell-derived molecule termed CTLAB. Recombinant HVS13 and CTLA8 stimulate transcriptional factor NF-κB activity and Interleukin-6 (IL-6) secretion in fibroblasts, and costimulate T cell proliferation. An HVS13.Fc fusion protein was used to isolate a cl)NA encoding a novel receptor that also binds CTLA8. This receptor is unrelated to previously Identified cytokine receptor families. A recombinant soluble receptor inhibited T cell proliferation and IL-2 production Induced by PHA, concanavalin A (conA), and anti-TCR MAb. These results define CTLA8 and HVS13 as novel cytokines that bind to a novel cytokine receptor. We propose to call these molecules IL-17, vIL-17, and IL-17R, respectively.

AB - Herpesvirus Saimiri gene 13 (HVS13) exhibits 57% identity with the predicted sequence of a T cell-derived molecule termed CTLAB. Recombinant HVS13 and CTLA8 stimulate transcriptional factor NF-κB activity and Interleukin-6 (IL-6) secretion in fibroblasts, and costimulate T cell proliferation. An HVS13.Fc fusion protein was used to isolate a cl)NA encoding a novel receptor that also binds CTLA8. This receptor is unrelated to previously Identified cytokine receptor families. A recombinant soluble receptor inhibited T cell proliferation and IL-2 production Induced by PHA, concanavalin A (conA), and anti-TCR MAb. These results define CTLA8 and HVS13 as novel cytokines that bind to a novel cytokine receptor. We propose to call these molecules IL-17, vIL-17, and IL-17R, respectively.

UR - http://www.scopus.com/inward/record.url?scp=0029555301&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029555301&partnerID=8YFLogxK

U2 - 10.1016/1074-7613(95)90070-5

DO - 10.1016/1074-7613(95)90070-5

M3 - Article

C2 - 8777726

AN - SCOPUS:0029555301

VL - 3

SP - 811

EP - 821

JO - Immunity

JF - Immunity

SN - 1074-7613

IS - 6

ER -