Abstract
Herpesvirus Saimiri gene 13 (HVS13) exhibits 57% identity with the predicted sequence of a T cell-derived molecule termed CTLAB. Recombinant HVS13 and CTLA8 stimulate transcriptional factor NF-κB activity and Interleukin-6 (IL-6) secretion in fibroblasts, and costimulate T cell proliferation. An HVS13.Fc fusion protein was used to isolate a cl)NA encoding a novel receptor that also binds CTLA8. This receptor is unrelated to previously Identified cytokine receptor families. A recombinant soluble receptor inhibited T cell proliferation and IL-2 production Induced by PHA, concanavalin A (conA), and anti-TCR MAb. These results define CTLA8 and HVS13 as novel cytokines that bind to a novel cytokine receptor. We propose to call these molecules IL-17, vIL-17, and IL-17R, respectively.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 811-821 |
| Number of pages | 11 |
| Journal | Immunity |
| Volume | 3 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1995 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Infectious Diseases
Cite this
Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. / Yao, Zhengbin; Fanslow, William C.; Seldin, Michael F; Rousseau, Anne Marie; Painter, Sally L.; Comeau, Michael R.; Cohen, Jeffrey I.; Spriggs, Melanie K.
In: Immunity, Vol. 3, No. 6, 1995, p. 811-821.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor
AU - Yao, Zhengbin
AU - Fanslow, William C.
AU - Seldin, Michael F
AU - Rousseau, Anne Marie
AU - Painter, Sally L.
AU - Comeau, Michael R.
AU - Cohen, Jeffrey I.
AU - Spriggs, Melanie K.
PY - 1995
Y1 - 1995
N2 - Herpesvirus Saimiri gene 13 (HVS13) exhibits 57% identity with the predicted sequence of a T cell-derived molecule termed CTLAB. Recombinant HVS13 and CTLA8 stimulate transcriptional factor NF-κB activity and Interleukin-6 (IL-6) secretion in fibroblasts, and costimulate T cell proliferation. An HVS13.Fc fusion protein was used to isolate a cl)NA encoding a novel receptor that also binds CTLA8. This receptor is unrelated to previously Identified cytokine receptor families. A recombinant soluble receptor inhibited T cell proliferation and IL-2 production Induced by PHA, concanavalin A (conA), and anti-TCR MAb. These results define CTLA8 and HVS13 as novel cytokines that bind to a novel cytokine receptor. We propose to call these molecules IL-17, vIL-17, and IL-17R, respectively.
AB - Herpesvirus Saimiri gene 13 (HVS13) exhibits 57% identity with the predicted sequence of a T cell-derived molecule termed CTLAB. Recombinant HVS13 and CTLA8 stimulate transcriptional factor NF-κB activity and Interleukin-6 (IL-6) secretion in fibroblasts, and costimulate T cell proliferation. An HVS13.Fc fusion protein was used to isolate a cl)NA encoding a novel receptor that also binds CTLA8. This receptor is unrelated to previously Identified cytokine receptor families. A recombinant soluble receptor inhibited T cell proliferation and IL-2 production Induced by PHA, concanavalin A (conA), and anti-TCR MAb. These results define CTLA8 and HVS13 as novel cytokines that bind to a novel cytokine receptor. We propose to call these molecules IL-17, vIL-17, and IL-17R, respectively.
UR - http://www.scopus.com/inward/record.url?scp=0029555301&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029555301&partnerID=8YFLogxK
U2 - 10.1016/1074-7613(95)90070-5
DO - 10.1016/1074-7613(95)90070-5
M3 - Article
C2 - 8777726
AN - SCOPUS:0029555301
VL - 3
SP - 811
EP - 821
JO - Immunity
JF - Immunity
SN - 1074-7613
IS - 6
ER -