Abstract
Herpesvirus Saimiri gene 13 (HVS13) exhibits 57% identity with the predicted sequence of a T cell-derived molecule termed CTLAB. Recombinant HVS13 and CTLA8 stimulate transcriptional factor NF-κB activity and Interleukin-6 (IL-6) secretion in fibroblasts, and costimulate T cell proliferation. An HVS13.Fc fusion protein was used to isolate a cl)NA encoding a novel receptor that also binds CTLA8. This receptor is unrelated to previously Identified cytokine receptor families. A recombinant soluble receptor inhibited T cell proliferation and IL-2 production Induced by PHA, concanavalin A (conA), and anti-TCR MAb. These results define CTLA8 and HVS13 as novel cytokines that bind to a novel cytokine receptor. We propose to call these molecules IL-17, vIL-17, and IL-17R, respectively.
Original language | English (US) |
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Pages (from-to) | 811-821 |
Number of pages | 11 |
Journal | Immunity |
Volume | 3 |
Issue number | 6 |
DOIs | |
State | Published - 1995 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Infectious Diseases