Abstract
Herpesvirus Saimiri gene 13 (HVS13) exhibits 57% identity with the predicted sequence of a T cell-derived molecule termed CTLA8. Recombinant HVS13 and CTLA8 stimulate transcriptional factor NF-kappaB activity and Interleukin-6 (IL-6) secretion in fibroblasts, and costimulate T cell proliferation. An HVS13.Fc fusion protein was used to isolate a cDNA encoding a novel receptor that also binds CTLA8. This receptor is unrelated to previously identified cytokine receptor families. A recombinant soluble receptor inhibited T cell proliferation and IL-2 production induced by PHA, concanavalin A (conA), and anti-TCR MAb. These results define CTLA8 and HVS13 as novel cytokines that bind to a novel cytokine receptor. We propose to call these molecules IL-17, vIL-17, and IL-17R, respectively.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4392-4402 |
| Number of pages | 11 |
| Journal | Journal of immunology (Baltimore, Md. : 1950) |
| Volume | 187 |
| Issue number | 9 |
| State | Published - Nov 1 2011 |
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Cite this
Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. / Yao, Zhengbin; Fanslow, William C.; Seldin, Michael F; Rousseau, Anne Marie; Painter, Sally L.; Comeau, Michael R.; Cohen, Jeffrey I.; Spriggs, Melanie K.
In: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, No. 9, 01.11.2011, p. 4392-4402.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor.
AU - Yao, Zhengbin
AU - Fanslow, William C.
AU - Seldin, Michael F
AU - Rousseau, Anne Marie
AU - Painter, Sally L.
AU - Comeau, Michael R.
AU - Cohen, Jeffrey I.
AU - Spriggs, Melanie K.
PY - 2011/11/1
Y1 - 2011/11/1
N2 - Herpesvirus Saimiri gene 13 (HVS13) exhibits 57% identity with the predicted sequence of a T cell-derived molecule termed CTLA8. Recombinant HVS13 and CTLA8 stimulate transcriptional factor NF-kappaB activity and Interleukin-6 (IL-6) secretion in fibroblasts, and costimulate T cell proliferation. An HVS13.Fc fusion protein was used to isolate a cDNA encoding a novel receptor that also binds CTLA8. This receptor is unrelated to previously identified cytokine receptor families. A recombinant soluble receptor inhibited T cell proliferation and IL-2 production induced by PHA, concanavalin A (conA), and anti-TCR MAb. These results define CTLA8 and HVS13 as novel cytokines that bind to a novel cytokine receptor. We propose to call these molecules IL-17, vIL-17, and IL-17R, respectively.
AB - Herpesvirus Saimiri gene 13 (HVS13) exhibits 57% identity with the predicted sequence of a T cell-derived molecule termed CTLA8. Recombinant HVS13 and CTLA8 stimulate transcriptional factor NF-kappaB activity and Interleukin-6 (IL-6) secretion in fibroblasts, and costimulate T cell proliferation. An HVS13.Fc fusion protein was used to isolate a cDNA encoding a novel receptor that also binds CTLA8. This receptor is unrelated to previously identified cytokine receptor families. A recombinant soluble receptor inhibited T cell proliferation and IL-2 production induced by PHA, concanavalin A (conA), and anti-TCR MAb. These results define CTLA8 and HVS13 as novel cytokines that bind to a novel cytokine receptor. We propose to call these molecules IL-17, vIL-17, and IL-17R, respectively.
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UR - http://www.scopus.com/inward/citedby.url?scp=84856052176&partnerID=8YFLogxK
M3 - Article
VL - 187
SP - 4392
EP - 4402
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 9
ER -