Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor.

Zhengbin Yao, William C. Fanslow, Michael F Seldin, Anne Marie Rousseau, Sally L. Painter, Michael R. Comeau, Jeffrey I. Cohen, Melanie K. Spriggs

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Herpesvirus Saimiri gene 13 (HVS13) exhibits 57% identity with the predicted sequence of a T cell-derived molecule termed CTLA8. Recombinant HVS13 and CTLA8 stimulate transcriptional factor NF-kappaB activity and Interleukin-6 (IL-6) secretion in fibroblasts, and costimulate T cell proliferation. An HVS13.Fc fusion protein was used to isolate a cDNA encoding a novel receptor that also binds CTLA8. This receptor is unrelated to previously identified cytokine receptor families. A recombinant soluble receptor inhibited T cell proliferation and IL-2 production induced by PHA, concanavalin A (conA), and anti-TCR MAb. These results define CTLA8 and HVS13 as novel cytokines that bind to a novel cytokine receptor. We propose to call these molecules IL-17, vIL-17, and IL-17R, respectively.

Original languageEnglish (US)
Pages (from-to)4392-4402
Number of pages11
JournalJournal of immunology (Baltimore, Md. : 1950)
Volume187
Issue number9
StatePublished - Nov 1 2011

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Saimiriine Herpesvirus 2
Cytokine Receptors
Interleukin-17
Cytokines
Genes
Cell Proliferation
T-Lymphocytes
NF-kappa B
Concanavalin A
Interleukin-2
Interleukin-6
Complementary DNA
Fibroblasts

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Yao, Z., Fanslow, W. C., Seldin, M. F., Rousseau, A. M., Painter, S. L., Comeau, M. R., ... Spriggs, M. K. (2011). Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Journal of immunology (Baltimore, Md. : 1950), 187(9), 4392-4402.

Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. / Yao, Zhengbin; Fanslow, William C.; Seldin, Michael F; Rousseau, Anne Marie; Painter, Sally L.; Comeau, Michael R.; Cohen, Jeffrey I.; Spriggs, Melanie K.

In: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, No. 9, 01.11.2011, p. 4392-4402.

Research output: Contribution to journalArticle

Yao, Z, Fanslow, WC, Seldin, MF, Rousseau, AM, Painter, SL, Comeau, MR, Cohen, JI & Spriggs, MK 2011, 'Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor.', Journal of immunology (Baltimore, Md. : 1950), vol. 187, no. 9, pp. 4392-4402.
Yao, Zhengbin ; Fanslow, William C. ; Seldin, Michael F ; Rousseau, Anne Marie ; Painter, Sally L. ; Comeau, Michael R. ; Cohen, Jeffrey I. ; Spriggs, Melanie K. / Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. In: Journal of immunology (Baltimore, Md. : 1950). 2011 ; Vol. 187, No. 9. pp. 4392-4402.
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