Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor.

Zhengbin Yao, William C. Fanslow, Michael F. Seldin, Anne Marie Rousseau, Sally L. Painter, Michael R. Comeau, Jeffrey I. Cohen, Melanie K. Spriggs

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Herpesvirus Saimiri gene 13 (HVS13) exhibits 57% identity with the predicted sequence of a T cell-derived molecule termed CTLA8. Recombinant HVS13 and CTLA8 stimulate transcriptional factor NF-kappaB activity and Interleukin-6 (IL-6) secretion in fibroblasts, and costimulate T cell proliferation. An HVS13.Fc fusion protein was used to isolate a cDNA encoding a novel receptor that also binds CTLA8. This receptor is unrelated to previously identified cytokine receptor families. A recombinant soluble receptor inhibited T cell proliferation and IL-2 production induced by PHA, concanavalin A (conA), and anti-TCR MAb. These results define CTLA8 and HVS13 as novel cytokines that bind to a novel cytokine receptor. We propose to call these molecules IL-17, vIL-17, and IL-17R, respectively.

Original languageEnglish (US)
Pages (from-to)4392-4402
Number of pages11
JournalJournal of immunology (Baltimore, Md. : 1950)
Volume187
Issue number9
StatePublished - Nov 1 2011

ASJC Scopus subject areas

  • Medicine(all)

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    Yao, Z., Fanslow, W. C., Seldin, M. F., Rousseau, A. M., Painter, S. L., Comeau, M. R., Cohen, J. I., & Spriggs, M. K. (2011). Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Journal of immunology (Baltimore, Md. : 1950), 187(9), 4392-4402.