Herpes zoster ophthalmicus: Acute keratitis

Research output: Contribution to journalReview article

Abstract

Purpose of review: Herpes zoster is a common condition, and involvement of the trigeminal nerve results in herpes zoster ophthalmicus (HZO). Acute keratitis is one of the most common of these ocular complications associated with HZO. The findings associated with and the management of acute zoster keratitis will be reviewed. Recent findings: The incidence rate of herpes zoster has been on the rise over the past several decades. At the same time, the average patient age at presentation is declining with similar trends also seen in HZO. The cause of these changes has yet to be determined. Our understanding of corneal involvement in HZO continues to evolve with new imaging demonstrating viral particles within keratocytes in a case of zoster stromal keratitis. New medications such as topical ganciclovir are also helping to better manage acute zoster keratitis that is unresponsive to oral antiviral therapy. Summary: Acute zoster keratitis can lead to permanent vision loss. Early diagnosis and management may help reduce these potentially devastating complications. Oral and topical antiviral medications can play a role in managing the acute disease, and herpes zoster vaccinations are important for prevention of disease. Further research must be done to establish standards for treatment of anterior segment complications from herpes zoster.

Original languageEnglish (US)
Pages (from-to)328-333
Number of pages6
JournalCurrent Opinion in Ophthalmology
Volume29
Issue number4
DOIs
StatePublished - Jul 1 2018

Fingerprint

Herpes Zoster Ophthalmicus
Keratitis
Herpes Zoster
Antiviral Agents
Ganciclovir
Trigeminal Nerve
Acute Disease
Virion
Early Diagnosis
Vaccination

Keywords

  • acute keratitis
  • herpes zoster ophthalmicus
  • zoster vaccine

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Herpes zoster ophthalmicus : Acute keratitis. / Li, Jennifer.

In: Current Opinion in Ophthalmology, Vol. 29, No. 4, 01.07.2018, p. 328-333.

Research output: Contribution to journalReview article

@article{57eedc6861594a32b5e06c044413336b,
title = "Herpes zoster ophthalmicus: Acute keratitis",
abstract = "Purpose of review: Herpes zoster is a common condition, and involvement of the trigeminal nerve results in herpes zoster ophthalmicus (HZO). Acute keratitis is one of the most common of these ocular complications associated with HZO. The findings associated with and the management of acute zoster keratitis will be reviewed. Recent findings: The incidence rate of herpes zoster has been on the rise over the past several decades. At the same time, the average patient age at presentation is declining with similar trends also seen in HZO. The cause of these changes has yet to be determined. Our understanding of corneal involvement in HZO continues to evolve with new imaging demonstrating viral particles within keratocytes in a case of zoster stromal keratitis. New medications such as topical ganciclovir are also helping to better manage acute zoster keratitis that is unresponsive to oral antiviral therapy. Summary: Acute zoster keratitis can lead to permanent vision loss. Early diagnosis and management may help reduce these potentially devastating complications. Oral and topical antiviral medications can play a role in managing the acute disease, and herpes zoster vaccinations are important for prevention of disease. Further research must be done to establish standards for treatment of anterior segment complications from herpes zoster.",
keywords = "acute keratitis, herpes zoster ophthalmicus, zoster vaccine",
author = "Jennifer Li",
year = "2018",
month = "7",
day = "1",
doi = "10.1097/ICU.0000000000000491",
language = "English (US)",
volume = "29",
pages = "328--333",
journal = "Current Opinion in Ophthalmology",
issn = "1040-8738",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Herpes zoster ophthalmicus

T2 - Acute keratitis

AU - Li, Jennifer

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Purpose of review: Herpes zoster is a common condition, and involvement of the trigeminal nerve results in herpes zoster ophthalmicus (HZO). Acute keratitis is one of the most common of these ocular complications associated with HZO. The findings associated with and the management of acute zoster keratitis will be reviewed. Recent findings: The incidence rate of herpes zoster has been on the rise over the past several decades. At the same time, the average patient age at presentation is declining with similar trends also seen in HZO. The cause of these changes has yet to be determined. Our understanding of corneal involvement in HZO continues to evolve with new imaging demonstrating viral particles within keratocytes in a case of zoster stromal keratitis. New medications such as topical ganciclovir are also helping to better manage acute zoster keratitis that is unresponsive to oral antiviral therapy. Summary: Acute zoster keratitis can lead to permanent vision loss. Early diagnosis and management may help reduce these potentially devastating complications. Oral and topical antiviral medications can play a role in managing the acute disease, and herpes zoster vaccinations are important for prevention of disease. Further research must be done to establish standards for treatment of anterior segment complications from herpes zoster.

AB - Purpose of review: Herpes zoster is a common condition, and involvement of the trigeminal nerve results in herpes zoster ophthalmicus (HZO). Acute keratitis is one of the most common of these ocular complications associated with HZO. The findings associated with and the management of acute zoster keratitis will be reviewed. Recent findings: The incidence rate of herpes zoster has been on the rise over the past several decades. At the same time, the average patient age at presentation is declining with similar trends also seen in HZO. The cause of these changes has yet to be determined. Our understanding of corneal involvement in HZO continues to evolve with new imaging demonstrating viral particles within keratocytes in a case of zoster stromal keratitis. New medications such as topical ganciclovir are also helping to better manage acute zoster keratitis that is unresponsive to oral antiviral therapy. Summary: Acute zoster keratitis can lead to permanent vision loss. Early diagnosis and management may help reduce these potentially devastating complications. Oral and topical antiviral medications can play a role in managing the acute disease, and herpes zoster vaccinations are important for prevention of disease. Further research must be done to establish standards for treatment of anterior segment complications from herpes zoster.

KW - acute keratitis

KW - herpes zoster ophthalmicus

KW - zoster vaccine

UR - http://www.scopus.com/inward/record.url?scp=85049248277&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049248277&partnerID=8YFLogxK

U2 - 10.1097/ICU.0000000000000491

DO - 10.1097/ICU.0000000000000491

M3 - Review article

C2 - 29794881

AN - SCOPUS:85049248277

VL - 29

SP - 328

EP - 333

JO - Current Opinion in Ophthalmology

JF - Current Opinion in Ophthalmology

SN - 1040-8738

IS - 4

ER -