Hereditary equine regional dermal asthenia ('hyperelastosis cutis') in 50 horses: Clinical, histological, immunohistological and ultrastructural findings

Stephen D White, Verena K Affolter, Danika L Bannasch, Patricia C. Schultheiss, Dwayne W. Hamar, Phillip L. Chapman, Diane Naydan, Sharon Spier, Rod A W Rosychuk, Christine Rees, Gregg O. Veneklasen, Alondra Martin, Diane Bevier, Hilary A. Jackson, Sonya Bettenay, Jennifer Matousek, Karen L. Campbell, Peter J. Ihrke

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Data on fifty horses with hereditary equine regional dermal asthenia (HERDA; 'hyperelastosis cutis') were collected on clinical, histopathological, ultrastructural and immunohistological findings. All horses were Quarter horses or of Quarter horse ancestry. Pedigree evaluation strongly supported an autosomal recessive mode of inheritance. The most common lesions were seromas/haematomas, open wounds, sloughing skin, and loose, easily tented skin that did not return to its initial position. Definitive diagnosis could not be made via histopathology, although the presence of tightly grouped thin and shortened collagen fibres arranged in clusters in the deep dermis was suggestive of the disease. Trichrome, acid orcein-Giemsa and immunohistochemical stains for collagens I and III showed no consistent abnormalities compared to control horses; an increase in elastic fibres was not a consistent finding. Electron microscopy showed no abnormalities in the periodicity of the collagen bundles; neither orientation nor variation of cross-section diameter of the collagen fibrils differentiated control from affected horses. The diagnosis of HERDA relies on clinical presentation, but may be supported by suggestive (although not pathognomonic) histopathological lesions.

Original languageEnglish (US)
Pages (from-to)207-217
Number of pages11
JournalVeterinary Dermatology
Volume15
Issue number4
DOIs
StatePublished - Aug 2004

Keywords

  • Collagen
  • HERDA
  • Hereditary equine regional dermal asthenia
  • Horses
  • Hyperelastosis cutis
  • Skin

ASJC Scopus subject areas

  • veterinary(all)

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    White, S. D., Affolter, V. K., Bannasch, D. L., Schultheiss, P. C., Hamar, D. W., Chapman, P. L., Naydan, D., Spier, S., Rosychuk, R. A. W., Rees, C., Veneklasen, G. O., Martin, A., Bevier, D., Jackson, H. A., Bettenay, S., Matousek, J., Campbell, K. L., & Ihrke, P. J. (2004). Hereditary equine regional dermal asthenia ('hyperelastosis cutis') in 50 horses: Clinical, histological, immunohistological and ultrastructural findings. Veterinary Dermatology, 15(4), 207-217. https://doi.org/10.1111/j.1365-3164.2004.00402.x