Hepatocellular carcinoma and associated clinical features in Latino and Caucasian patients from a single center

Gabriela N. Kuftinec, Robert Levy, Dorothy A. Kieffer, Valentina Medici

Research output: Contribution to journalArticle

Abstract

Introduction and aim. Hepatocellular carcinoma (HCC) is the most common type of liver cancer in adults and has seen a rapid increase in incidence in the United States. Racial and ethnic differences in HCC incidence have been observed, with Latinos showing the greatest increase over the past four decades, highlighting a concerning health disparity. The goal of the present study was to compare the clinical features at the time of diagnosis of HCC in Latino and Caucasian patients. Material and methods. We retrospectively screened a total of 556 charts of Latino and Caucasian patients with HCC. Results. The mean age of HCC diagnosis was not significantly different between Latinos and Caucasians, but Latinos presented with higher body mass index (BMI). Rates of hypertension, diabetes, and hyperlipidemia were similar in the two groups. The most common etiology of liver disease was alcohol drinking in Latinos, and chronic hepatitis C in Caucasian patients. Non-Alcoholic Steatohepatitis (NASH) was the associated diagnosis in 8.6% of Latinos and 4.7% of Caucasians. Interestingly, alpha-fetoprotein (AFP) levels at time of diagnosis were higher in Latino patients compared to Caucasians, but this difference was evident only in male patients. Multifocal HCC was slightly more frequent in Latinos, but the two groups had similar cancerous vascular invasion. Latino patients also presented with higher rates of both ascites and hepatic encephalopathy. Conclusion. Latino and Caucasian patients with HCC present with a different profile of etiologies, but cancer features appear to be more severe in Latinos.

Original languageEnglish (US)
Pages (from-to)177-186
Number of pages10
JournalAnnals of Hepatology
Volume18
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

Hispanic Americans
Hepatocellular Carcinoma
Hepatic Encephalopathy
Incidence
alpha-Fetoproteins
Chronic Hepatitis C
Fatty Liver
Hyperlipidemias
Ascites
Alcohol Drinking
Blood Vessels
Liver Diseases
Body Mass Index
Hypertension

Keywords

  • Alcoholic cirrhosis
  • Cirrhosis
  • Ethnicity
  • Hepatitis C virus (HCV)

ASJC Scopus subject areas

  • Hepatology

Cite this

Hepatocellular carcinoma and associated clinical features in Latino and Caucasian patients from a single center. / Kuftinec, Gabriela N.; Levy, Robert; Kieffer, Dorothy A.; Medici, Valentina.

In: Annals of Hepatology, Vol. 18, No. 1, 01.01.2019, p. 177-186.

Research output: Contribution to journalArticle

Kuftinec, Gabriela N. ; Levy, Robert ; Kieffer, Dorothy A. ; Medici, Valentina. / Hepatocellular carcinoma and associated clinical features in Latino and Caucasian patients from a single center. In: Annals of Hepatology. 2019 ; Vol. 18, No. 1. pp. 177-186.
@article{32c8321db72943a49e674ec922cf7f5f,
title = "Hepatocellular carcinoma and associated clinical features in Latino and Caucasian patients from a single center",
abstract = "Introduction and aim. Hepatocellular carcinoma (HCC) is the most common type of liver cancer in adults and has seen a rapid increase in incidence in the United States. Racial and ethnic differences in HCC incidence have been observed, with Latinos showing the greatest increase over the past four decades, highlighting a concerning health disparity. The goal of the present study was to compare the clinical features at the time of diagnosis of HCC in Latino and Caucasian patients. Material and methods. We retrospectively screened a total of 556 charts of Latino and Caucasian patients with HCC. Results. The mean age of HCC diagnosis was not significantly different between Latinos and Caucasians, but Latinos presented with higher body mass index (BMI). Rates of hypertension, diabetes, and hyperlipidemia were similar in the two groups. The most common etiology of liver disease was alcohol drinking in Latinos, and chronic hepatitis C in Caucasian patients. Non-Alcoholic Steatohepatitis (NASH) was the associated diagnosis in 8.6{\%} of Latinos and 4.7{\%} of Caucasians. Interestingly, alpha-fetoprotein (AFP) levels at time of diagnosis were higher in Latino patients compared to Caucasians, but this difference was evident only in male patients. Multifocal HCC was slightly more frequent in Latinos, but the two groups had similar cancerous vascular invasion. Latino patients also presented with higher rates of both ascites and hepatic encephalopathy. Conclusion. Latino and Caucasian patients with HCC present with a different profile of etiologies, but cancer features appear to be more severe in Latinos.",
keywords = "Alcoholic cirrhosis, Cirrhosis, Ethnicity, Hepatitis C virus (HCV)",
author = "Kuftinec, {Gabriela N.} and Robert Levy and Kieffer, {Dorothy A.} and Valentina Medici",
year = "2019",
month = "1",
day = "1",
doi = "10.5604/01.3001.0012.7910",
language = "English (US)",
volume = "18",
pages = "177--186",
journal = "Annals of Hepatology",
issn = "1665-2681",
publisher = "Mexican Association of Hepatology",
number = "1",

}

TY - JOUR

T1 - Hepatocellular carcinoma and associated clinical features in Latino and Caucasian patients from a single center

AU - Kuftinec, Gabriela N.

AU - Levy, Robert

AU - Kieffer, Dorothy A.

AU - Medici, Valentina

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Introduction and aim. Hepatocellular carcinoma (HCC) is the most common type of liver cancer in adults and has seen a rapid increase in incidence in the United States. Racial and ethnic differences in HCC incidence have been observed, with Latinos showing the greatest increase over the past four decades, highlighting a concerning health disparity. The goal of the present study was to compare the clinical features at the time of diagnosis of HCC in Latino and Caucasian patients. Material and methods. We retrospectively screened a total of 556 charts of Latino and Caucasian patients with HCC. Results. The mean age of HCC diagnosis was not significantly different between Latinos and Caucasians, but Latinos presented with higher body mass index (BMI). Rates of hypertension, diabetes, and hyperlipidemia were similar in the two groups. The most common etiology of liver disease was alcohol drinking in Latinos, and chronic hepatitis C in Caucasian patients. Non-Alcoholic Steatohepatitis (NASH) was the associated diagnosis in 8.6% of Latinos and 4.7% of Caucasians. Interestingly, alpha-fetoprotein (AFP) levels at time of diagnosis were higher in Latino patients compared to Caucasians, but this difference was evident only in male patients. Multifocal HCC was slightly more frequent in Latinos, but the two groups had similar cancerous vascular invasion. Latino patients also presented with higher rates of both ascites and hepatic encephalopathy. Conclusion. Latino and Caucasian patients with HCC present with a different profile of etiologies, but cancer features appear to be more severe in Latinos.

AB - Introduction and aim. Hepatocellular carcinoma (HCC) is the most common type of liver cancer in adults and has seen a rapid increase in incidence in the United States. Racial and ethnic differences in HCC incidence have been observed, with Latinos showing the greatest increase over the past four decades, highlighting a concerning health disparity. The goal of the present study was to compare the clinical features at the time of diagnosis of HCC in Latino and Caucasian patients. Material and methods. We retrospectively screened a total of 556 charts of Latino and Caucasian patients with HCC. Results. The mean age of HCC diagnosis was not significantly different between Latinos and Caucasians, but Latinos presented with higher body mass index (BMI). Rates of hypertension, diabetes, and hyperlipidemia were similar in the two groups. The most common etiology of liver disease was alcohol drinking in Latinos, and chronic hepatitis C in Caucasian patients. Non-Alcoholic Steatohepatitis (NASH) was the associated diagnosis in 8.6% of Latinos and 4.7% of Caucasians. Interestingly, alpha-fetoprotein (AFP) levels at time of diagnosis were higher in Latino patients compared to Caucasians, but this difference was evident only in male patients. Multifocal HCC was slightly more frequent in Latinos, but the two groups had similar cancerous vascular invasion. Latino patients also presented with higher rates of both ascites and hepatic encephalopathy. Conclusion. Latino and Caucasian patients with HCC present with a different profile of etiologies, but cancer features appear to be more severe in Latinos.

KW - Alcoholic cirrhosis

KW - Cirrhosis

KW - Ethnicity

KW - Hepatitis C virus (HCV)

UR - http://www.scopus.com/inward/record.url?scp=85059289523&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85059289523&partnerID=8YFLogxK

U2 - 10.5604/01.3001.0012.7910

DO - 10.5604/01.3001.0012.7910

M3 - Article

C2 - 30596601

AN - SCOPUS:85059289523

VL - 18

SP - 177

EP - 186

JO - Annals of Hepatology

JF - Annals of Hepatology

SN - 1665-2681

IS - 1

ER -