Abstract
Purpose of review: As a rare pediatric tumor, hepatoblastoma presents challenges to the individual practitioner as no center will see more than a handful of cases each year. Recent findings: The ChildrenÊs Hepatic tumor International Collaborative (CHIC) effort has fostered international cooperation in this rare childrenÊs tumor, leading to the establishment of a large international collaborative dataset, the CHIC database, which has been interrogated to refine risk stratification and inform treatment options. Apace with this effort has been the international collaboration of pediatric pathologists working together to establish a new international histopathologic consensus classification for pediatric liver tumors as a whole, with particular focus on the histological subtypes of hepatoblastoma. Summary: International collaborative efforts in hepatoblastoma have led to a new international histopathologic consensus classification, refinements in risk stratification, advances in chemotherapy, and a better understanding of surgical resection options forming the foundation for the development of an upcoming international therapeutic trial.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 19-28 |
| Number of pages | 10 |
| Journal | Current Opinion in Pediatrics |
| Volume | 26 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 1 2014 |
| Externally published | Yes |
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Keywords
- chemotherapy
- genetics
- hepatoblastoma
- pathology
- risk stratification
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Hepatoblastoma state of the art : Pathology, genetics, risk stratification, and chemotherapy. / Czauderna, Piotr; Lopez-Terrada, Dolores; Hiyama, Eiso; Häberle, Beate; Malogolowkin, Marcio; Meyers, Rebecka L.
In: Current Opinion in Pediatrics, Vol. 26, No. 1, 01.02.2014, p. 19-28.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Hepatoblastoma state of the art
T2 - Pathology, genetics, risk stratification, and chemotherapy
AU - Czauderna, Piotr
AU - Lopez-Terrada, Dolores
AU - Hiyama, Eiso
AU - Häberle, Beate
AU - Malogolowkin, Marcio
AU - Meyers, Rebecka L.
PY - 2014/2/1
Y1 - 2014/2/1
N2 - Purpose of review: As a rare pediatric tumor, hepatoblastoma presents challenges to the individual practitioner as no center will see more than a handful of cases each year. Recent findings: The ChildrenÊs Hepatic tumor International Collaborative (CHIC) effort has fostered international cooperation in this rare childrenÊs tumor, leading to the establishment of a large international collaborative dataset, the CHIC database, which has been interrogated to refine risk stratification and inform treatment options. Apace with this effort has been the international collaboration of pediatric pathologists working together to establish a new international histopathologic consensus classification for pediatric liver tumors as a whole, with particular focus on the histological subtypes of hepatoblastoma. Summary: International collaborative efforts in hepatoblastoma have led to a new international histopathologic consensus classification, refinements in risk stratification, advances in chemotherapy, and a better understanding of surgical resection options forming the foundation for the development of an upcoming international therapeutic trial.
AB - Purpose of review: As a rare pediatric tumor, hepatoblastoma presents challenges to the individual practitioner as no center will see more than a handful of cases each year. Recent findings: The ChildrenÊs Hepatic tumor International Collaborative (CHIC) effort has fostered international cooperation in this rare childrenÊs tumor, leading to the establishment of a large international collaborative dataset, the CHIC database, which has been interrogated to refine risk stratification and inform treatment options. Apace with this effort has been the international collaboration of pediatric pathologists working together to establish a new international histopathologic consensus classification for pediatric liver tumors as a whole, with particular focus on the histological subtypes of hepatoblastoma. Summary: International collaborative efforts in hepatoblastoma have led to a new international histopathologic consensus classification, refinements in risk stratification, advances in chemotherapy, and a better understanding of surgical resection options forming the foundation for the development of an upcoming international therapeutic trial.
KW - chemotherapy
KW - genetics
KW - hepatoblastoma
KW - pathology
KW - risk stratification
UR - http://www.scopus.com/inward/record.url?scp=84894644250&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84894644250&partnerID=8YFLogxK
U2 - 10.1097/MOP.0000000000000046
DO - 10.1097/MOP.0000000000000046
M3 - Review article
C2 - 24322718
AN - SCOPUS:84894644250
VL - 26
SP - 19
EP - 28
JO - Current Opinion in Pediatrics
JF - Current Opinion in Pediatrics
SN - 1040-8703
IS - 1
ER -