Hepatitis B virus (HBV) and autoimmune disease

Ram Maya, M. Eric Gershwin, Yehuda Shoenfeld

Research output: Contribution to journalArticle

79 Scopus citations

Abstract

The etiology and pathogenesis of autoimmune diseases have long been an enigmatic subject that have involved genetic and environmental factors. Recent intriguing data has contributed to the mechanisms involved, including the relationship of infectious agents and loss of tolerance. This loss of tolerance is illustrated by the data on the immune response to Hepatitis B virus such as the molecular mimicry between HBV antigens and self proteins, the generation of immune complexes between HBV antigens and antibodies, and apoptosis/tissue damage resulting in the exposure of intracellular antigens to the immune system. In this paper, we review the current database related to HBV infection and a variety of autoimmune conditions, including autoimmune hepatitis, systemic lupus erythematosus, aplastic anemia, antiphospholipid syndrome, polyarteritis nodosa, rheumatoid arthritis, type 1 diabetes, multiple sclerosis, thyroid disease and uveitis.

Original languageEnglish (US)
Pages (from-to)85-102
Number of pages18
JournalClinical Reviews in Allergy and Immunology
Volume34
Issue number1
DOIs
StatePublished - Feb 2008

Keywords

  • Antiphospholipid syndrome
  • Autoimmune disease
  • Autoimmune hepatitis
  • Hepatitis B virus
  • Multiple sclerosis
  • Polyarteritis nodosa
  • Rheumatoid arthritis
  • Systemic lupus erythomatosus
  • Thyroid disease and uveitis
  • Type 1 diabetes

ASJC Scopus subject areas

  • Immunology and Allergy

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