Abstract
One hundred seven Chinese patients with primary hepatocellular carcinoma (PHC) were compared with 107 hospital controls for the presence of hepatitis B surface antigen and smoking, drinking, and dietary habits. 82% of PHC cases were hepatitis B surface antigen positive compared to 18% of controls (relative risk, 21.3; 95% confidence limits, 10.1 and 45.9). Prior history of jaundice was significantly related to PHC, independent of hepatitis B surface antigen status. There was a significant association between cigarette smoking and PHC negative for hepatitis B surface antigen. The relative risk of hepatitis B surface antigen-negative PHC for heavy smokers (20+ cigarettes/day) was 3.3 compared to light smokers and nonsmokers (95% confidence limits, 1.0 and 13.4). Our data indicated that infection by the hepatitis B virus and cigarette smoking were independent risk factors for PHC.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5246-5248 |
| Number of pages | 3 |
| Journal | Cancer Research |
| Volume | 42 |
| Issue number | 12 |
| State | Published - 1982 |
| Externally published | Yes |
ASJC Scopus subject areas
- Cancer Research
- Oncology