Hepatitis B and C viral load changes following initiation of highly active antiretroviral therapy (HAART) in patients with advanced HIV infection

David Asmuth, Michael P. Busch, Megan E. Laycock, Beth A. Mohr, Leslie A. Kalish, Charles M. Van Der Horst

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Chronic infection with either hepatitis B (HBV) or hepatitis C virus (HCV) is frequently present in patients seropositive for human immunodeficiency virus (HIV) because of shared routes of transmission. With the advent of highly active antiretroviral therapy (HAART) regimens capable of controlling HIV replication and dramatically prolonging the survival of HIV-infected patients, the impact of co-morbid infections such as HBV and HCV has come into focus. Several studies have monitored HBV or HCV viral loads following initiation of HAART, with disparate results. The effects of HAART on hepatitis B and C plasma viral loads (n=9 and 32, respectively) and on liver enzyme levels were studied in a large cohort of prospectively studied subjects with advanced stage HIV disease. Comparing the mean pre- and post-HAART levels, there was an estimated increase of (a) 1.40 log10 from 4.83 to 6.24 log10 for HBV plasma viral load (P=0.07), (b) 0.74 log10 from 6.38 to 7.12 log 10 for HCV plasma viral load (P=0.001), and (c) 19.4 U/L from 37.4 to 56.8 U/L for serum alanine aminotransferase (P<0.001). While the number of subjects co-infected with HIV and HBV was limited, these data collected in a population of advanced stage HIV-infected patients raises questions regarding the interactions of these viruses with each other and the host immune system and has implications regarding the order in which antiviral therapies are initiated.

Original languageEnglish (US)
Pages (from-to)123-131
Number of pages9
JournalAntiviral Research
Volume63
Issue number2
DOIs
StatePublished - Aug 2004

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Keywords

  • Antiretroviral therapy
  • Hepatitis B
  • Hepatitis C
  • Human immunodeficiency virus
  • Viral load

ASJC Scopus subject areas

  • Virology
  • Pharmacology

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