Hepatic osteodystrophy in a golden lion tamarin (Leontopithecus rosalia)

Eun ju Choi, Sara E. Childs-Sanford, Noha Abou-Madi, Erin E. King, Brian G. Caserto, Heather Priest, Erica Behling-Kelly, Andrew D. Miller

Research output: Contribution to journalArticlepeer-review


An 8-yr-old, captive, female golden lion tamarin (Leontopithecus rosalia) with a 6-yr history of hyperbilirubinemia was examined for inappetence and weight loss. Physical examination and blood pressure monitoring under anesthesia revealed hypothermia and hypotension, and blood work revealed hypoglycemia, markedly elevated liver enzymes, including serum alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase, and confirmed the hyperbilirubinemia. A complete blood count suggested chronic lymphoid leukemia. The animal's condition deteriorated during recovery, and the animal died despite aggressive treatment. Grossly, there was micronodular cirrhosis of the liver, severe icterus, and diffuse osteopenia of all examined bones. Microscopic examination of the liver confirmed the micronodular cirrhosis and bone lesions were compatible with diffuse osteopenia and osteomalacia. This brief communication presents a case of chronic liver disease and lesions indicative of metabolic bone disease, also known as hepatic osteodystrophy. To the authors' knowledge, this is the first documented case of hepatic osteodystrophy in the veterinary literature.

Original languageEnglish (US)
Pages (from-to)907-911
Number of pages5
JournalJournal of Zoo and Wildlife Medicine
Issue number3
StatePublished - Sep 1 2016
Externally publishedYes


  • Cirrhosis
  • Golden lion tamarin
  • hepatic osteodystrophy
  • hyperbilirubinemia
  • Leontopithecus rosalia

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)


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