Hepatic enzyme response and hyperpyrexia after severe liver injury

T. H. Cogbill, E. E. Moore, D. V. Feliciano, Gregory Jurkovich, J. A. Morris, P. Mucha

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A multi-center experience with 210 severe liver injuries was reviewed to define postoperative changes in hepatic enzyme levels and body temperature profile. The 129 patients who survived initial operation comprised the data base. Serum glutamic oxaloacetic transaminase (SGOT) and lactate dehydrogenase (LDH) peaked within 24 hours (750 ± 92 IU/L, 870 ± 120 IU/L) and decreased rapidly during the first 4 days. Serum bilirubin was maximal at 7 days, while alkaline phosphatase rose slowly throughout 14 days. Hepatic enzyme elevations were more dramatic after blunt trauma, reflecting greater hepatocellular disruption. Maximum daily temperatures exceeding 38.0°C and 39.0°C were recorded for the first 3 postoperative days in 82 (64%) patients and 14 (11%) patients, respectively. No infectious source was evident in 13 (93%) of 14 patients with severe hyperpyrexia, implicating release of inflammatory mediators associated with major hepatic trauma. Convalescence from severe hepatic injury is marked by release of SGOT and LDH, as well as fever, which may be anticipated during the first 4 days postinjury.

Original languageEnglish (US)
Pages (from-to)395-399
Number of pages5
JournalAmerican Surgeon
Volume58
Issue number7
StatePublished - Jan 1 1992
Externally publishedYes

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Liver
Wounds and Injuries
Enzymes
Aspartate Aminotransferases
L-Lactate Dehydrogenase
Body Temperature
Bilirubin
Alkaline Phosphatase
Fever
Databases
Temperature
Serum

ASJC Scopus subject areas

  • Surgery

Cite this

Cogbill, T. H., Moore, E. E., Feliciano, D. V., Jurkovich, G., Morris, J. A., & Mucha, P. (1992). Hepatic enzyme response and hyperpyrexia after severe liver injury. American Surgeon, 58(7), 395-399.

Hepatic enzyme response and hyperpyrexia after severe liver injury. / Cogbill, T. H.; Moore, E. E.; Feliciano, D. V.; Jurkovich, Gregory; Morris, J. A.; Mucha, P.

In: American Surgeon, Vol. 58, No. 7, 01.01.1992, p. 395-399.

Research output: Contribution to journalArticle

Cogbill, TH, Moore, EE, Feliciano, DV, Jurkovich, G, Morris, JA & Mucha, P 1992, 'Hepatic enzyme response and hyperpyrexia after severe liver injury', American Surgeon, vol. 58, no. 7, pp. 395-399.
Cogbill TH, Moore EE, Feliciano DV, Jurkovich G, Morris JA, Mucha P. Hepatic enzyme response and hyperpyrexia after severe liver injury. American Surgeon. 1992 Jan 1;58(7):395-399.
Cogbill, T. H. ; Moore, E. E. ; Feliciano, D. V. ; Jurkovich, Gregory ; Morris, J. A. ; Mucha, P. / Hepatic enzyme response and hyperpyrexia after severe liver injury. In: American Surgeon. 1992 ; Vol. 58, No. 7. pp. 395-399.
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