Hepatic dysfunction and jaundice following high-dose cytosine arabinoside

C. B. George, R. P. Mansour, J. Redmond, David R Gandara

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Two patients with poor-prognosis leukemia were treated with high-dose cytosine arabinoside (Ara-C), 3 g/m2, for induction. Both patients developed serious jaundice in the second posttreatment week. Clinically, the jaundice was characterized by conjugated hyperbilirubinemia, normal amino transferase levels, significant elevation of alkaline phosphatase, and no evidence of obstruction. Microscopic examination of the liver showed only passive congestion with blood, and no bile lakes or plugs. This was believed to be most consistent with drug-induced intrahepatic cholestasis, possibly as a result of injury to the hepatocyte transport system.

Original languageEnglish (US)
Pages (from-to)2360-2362
Number of pages3
JournalCancer
Volume54
Issue number11
StatePublished - 1984
Externally publishedYes

Fingerprint

Cytarabine
Jaundice
Intrahepatic Cholestasis
Hyperbilirubinemia
Liver
Lakes
Transferases
Bile
Alkaline Phosphatase
Hepatocytes
Leukemia
Wounds and Injuries
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

George, C. B., Mansour, R. P., Redmond, J., & Gandara, D. R. (1984). Hepatic dysfunction and jaundice following high-dose cytosine arabinoside. Cancer, 54(11), 2360-2362.

Hepatic dysfunction and jaundice following high-dose cytosine arabinoside. / George, C. B.; Mansour, R. P.; Redmond, J.; Gandara, David R.

In: Cancer, Vol. 54, No. 11, 1984, p. 2360-2362.

Research output: Contribution to journalArticle

George, CB, Mansour, RP, Redmond, J & Gandara, DR 1984, 'Hepatic dysfunction and jaundice following high-dose cytosine arabinoside', Cancer, vol. 54, no. 11, pp. 2360-2362.
George, C. B. ; Mansour, R. P. ; Redmond, J. ; Gandara, David R. / Hepatic dysfunction and jaundice following high-dose cytosine arabinoside. In: Cancer. 1984 ; Vol. 54, No. 11. pp. 2360-2362.
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