Heparin, lipoproteins, and oxygenated fatty acids in blood: A cautionary note

T. L. Goodfriend, T. L. Pedersen, R. J. Grekin, B. D. Hammock, D. L. Ball, A. Vollmer

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We measured 16 nonesterified oxygenated fatty acid derivatives (oxylipids) in plasmas from seven human subjects. Two arterial samples from each subject were analyzed, drawn approximately 2 h apart. We observed a marked increase in levels of most oxylipids in the second sample, as high as 470-fold. Between the first and second samples, subjects received approximately 800-1000 IU of heparin to prevent clotting in intravascular catheters. We postulate that heparin activated lipoprotein lipases, which, in turn, released oxylipids from triglycerides and phospholipids in plasma lipoproteins. Some of that lipolysis may have occurred during sample storage. Measurements of nonesterified lipids in human plasma may be distorted if heparin is administered to subjects before blood is drawn and if lipase inhibitors are omitted from stored samples.

Original languageEnglish (US)
Pages (from-to)363-366
Number of pages4
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume77
Issue number5-6
DOIs
StatePublished - Nov 2007

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Lipoproteins
Heparin
Blood
Fatty Acids
Plasma (human)
Plasmas
Lipoprotein Lipase
Catheters
Lipolysis
Lipase
Nonesterified Fatty Acids
Phospholipids
Triglycerides
Derivatives
Lipids

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Goodfriend, T. L., Pedersen, T. L., Grekin, R. J., Hammock, B. D., Ball, D. L., & Vollmer, A. (2007). Heparin, lipoproteins, and oxygenated fatty acids in blood: A cautionary note. Prostaglandins Leukotrienes and Essential Fatty Acids, 77(5-6), 363-366. https://doi.org/10.1016/j.plefa.2007.10.012

Heparin, lipoproteins, and oxygenated fatty acids in blood : A cautionary note. / Goodfriend, T. L.; Pedersen, T. L.; Grekin, R. J.; Hammock, B. D.; Ball, D. L.; Vollmer, A.

In: Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 77, No. 5-6, 11.2007, p. 363-366.

Research output: Contribution to journalArticle

Goodfriend, TL, Pedersen, TL, Grekin, RJ, Hammock, BD, Ball, DL & Vollmer, A 2007, 'Heparin, lipoproteins, and oxygenated fatty acids in blood: A cautionary note', Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 77, no. 5-6, pp. 363-366. https://doi.org/10.1016/j.plefa.2007.10.012
Goodfriend, T. L. ; Pedersen, T. L. ; Grekin, R. J. ; Hammock, B. D. ; Ball, D. L. ; Vollmer, A. / Heparin, lipoproteins, and oxygenated fatty acids in blood : A cautionary note. In: Prostaglandins Leukotrienes and Essential Fatty Acids. 2007 ; Vol. 77, No. 5-6. pp. 363-366.
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