Heparin, lipoproteins, and oxygenated fatty acids in blood: A cautionary note

T. L. Goodfriend, T. L. Pedersen, R. J. Grekin, B. D. Hammock, D. L. Ball, A. Vollmer

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


We measured 16 nonesterified oxygenated fatty acid derivatives (oxylipids) in plasmas from seven human subjects. Two arterial samples from each subject were analyzed, drawn approximately 2 h apart. We observed a marked increase in levels of most oxylipids in the second sample, as high as 470-fold. Between the first and second samples, subjects received approximately 800-1000 IU of heparin to prevent clotting in intravascular catheters. We postulate that heparin activated lipoprotein lipases, which, in turn, released oxylipids from triglycerides and phospholipids in plasma lipoproteins. Some of that lipolysis may have occurred during sample storage. Measurements of nonesterified lipids in human plasma may be distorted if heparin is administered to subjects before blood is drawn and if lipase inhibitors are omitted from stored samples.

Original languageEnglish (US)
Pages (from-to)363-366
Number of pages4
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Issue number5-6
StatePublished - Nov 2007

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Endocrinology, Diabetes and Metabolism


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