Abstract
Amounts of thromboxane A2 (TXA2) synthesized during the collagen-induced aggregation was much higher in citrated PRP than in heaprinized PRP implying that heparin might inhibit the synthesis of endoperoxide metabolites besides its anticoagulant action. Preincubation of citrated PRP with heparin resulted in dose dependent inhibition of the formation of TXA2 and PGE2. At the high concentration, heparin also inhibited the aggregation of citrated platelets induced by collagen indicating that heparin possesses aspirin-like activity. The significance of this finding is that the antithrombotic effect of heparin is probably due to not only its anticoagulant effect but also inhibition of the formation of arachidonic acid metabolites by platelets.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 341-344 |
| Number of pages | 4 |
| Journal | Prostaglandines and Medicine |
| Volume | 6 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1981 |
| Externally published | Yes |
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Cite this
Heparin inhibits the formation of endoperoxide metabolites in rat platelets : aspirin-like activity. / Hwang, Daniel H.; LeBlanc, P.
In: Prostaglandines and Medicine, Vol. 6, No. 4, 1981, p. 341-344.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Heparin inhibits the formation of endoperoxide metabolites in rat platelets
T2 - aspirin-like activity
AU - Hwang, Daniel H.
AU - LeBlanc, P.
PY - 1981
Y1 - 1981
N2 - Amounts of thromboxane A2 (TXA2) synthesized during the collagen-induced aggregation was much higher in citrated PRP than in heaprinized PRP implying that heparin might inhibit the synthesis of endoperoxide metabolites besides its anticoagulant action. Preincubation of citrated PRP with heparin resulted in dose dependent inhibition of the formation of TXA2 and PGE2. At the high concentration, heparin also inhibited the aggregation of citrated platelets induced by collagen indicating that heparin possesses aspirin-like activity. The significance of this finding is that the antithrombotic effect of heparin is probably due to not only its anticoagulant effect but also inhibition of the formation of arachidonic acid metabolites by platelets.
AB - Amounts of thromboxane A2 (TXA2) synthesized during the collagen-induced aggregation was much higher in citrated PRP than in heaprinized PRP implying that heparin might inhibit the synthesis of endoperoxide metabolites besides its anticoagulant action. Preincubation of citrated PRP with heparin resulted in dose dependent inhibition of the formation of TXA2 and PGE2. At the high concentration, heparin also inhibited the aggregation of citrated platelets induced by collagen indicating that heparin possesses aspirin-like activity. The significance of this finding is that the antithrombotic effect of heparin is probably due to not only its anticoagulant effect but also inhibition of the formation of arachidonic acid metabolites by platelets.
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U2 - 10.1016/0161-4630(81)90065-3
DO - 10.1016/0161-4630(81)90065-3
M3 - Article
VL - 6
SP - 341
EP - 344
JO - Prostaglandins Leukotrienes and Essential Fatty Acids
JF - Prostaglandins Leukotrienes and Essential Fatty Acids
SN - 0952-3278
IS - 4
ER -