Hemoglobin oxygen saturation targets in the neonatal intensive care unit

Is there a light at the end of the tunnel? 1

Research output: Contribution to journalReview article

Abstract

The optimal oxygenation target needed to prevent the extremes of hypoxia and oxygen toxicity in premature and sick newborns has been the subject of much research and debate. The advent of the pulse oximeter has allowed the continuous monitoring of oxyhemoglobin saturation and the delivery of oxygen with greater precision. Well-run, large clinical trials to determine the safest oxygen concentration have led to several revisions in guidelines for neonatal care. However, monitoring of oxyhemoglobin saturation has its limitations and does not provide a comprehensive assessment of tissue oxygenation. To identify optimal oxygen therapy, various other factors (partial pressure of arterial carbon dioxide, hemoglobin concentration, blood pH, and tissue metabolic demand) that influence perfusion and tissue oxygenation need to be considered.

Original languageEnglish (US)
Pages (from-to)174-182
Number of pages9
JournalCanadian Journal of Physiology and Pharmacology
Volume97
Issue number3
DOIs
StatePublished - Jan 1 2019

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Neonatal Intensive Care Units
Hemoglobins
Oxygen
Oxyhemoglobins
Partial Pressure
Carbon Dioxide
Perfusion
Clinical Trials
Guidelines
Research
Therapeutics

Keywords

  • Newborn
  • Oxygen saturation
  • Oxygen target

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

Cite this

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AB - The optimal oxygenation target needed to prevent the extremes of hypoxia and oxygen toxicity in premature and sick newborns has been the subject of much research and debate. The advent of the pulse oximeter has allowed the continuous monitoring of oxyhemoglobin saturation and the delivery of oxygen with greater precision. Well-run, large clinical trials to determine the safest oxygen concentration have led to several revisions in guidelines for neonatal care. However, monitoring of oxyhemoglobin saturation has its limitations and does not provide a comprehensive assessment of tissue oxygenation. To identify optimal oxygen therapy, various other factors (partial pressure of arterial carbon dioxide, hemoglobin concentration, blood pH, and tissue metabolic demand) that influence perfusion and tissue oxygenation need to be considered.

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