Hemodynamics and gas exchange during chest compressions in neonatal resuscitation

Payam Vali, Praveen Chandrasekharan, Munmun Rawat, Sylvia Gugino, Carmon Koenigsknecht, Justin Helman, Bobby Mathew, Sara Berkelhamer, Jayasree Nair, Myra Wyckoff, Satyanarayana Lakshminrusimha

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Purpose Current knowledge about pulmonary/systemic hemodynamics and gas exchange during neonatal resuscitation in a model of transitioning fetal circulation with fetal shunts and fluidfilled alveoli is limited. Using a fetal lamb asphyxia model, we sought to determine whether hemodynamic or gas-exchange parameters predicted successful return of spontaneous circulation (ROSC). Methods The umbilical cord was occluded in 22 lambs to induce asphyxial cardiac arrest. Following five minutes of asystole, resuscitation as per AHA-Neonatal Resuscitation Program guidelines was initiated. Hemodynamic parameters and serial arterial blood gases were assessed during resuscitation. Results ROSC occurred in 18 lambs (82%) at a median (IQR) time of 120 (105-180) seconds. There were no differences in hemodynamic parameters at baseline and at any given time point during resuscitation between the lambs that achieved ROSC and those that did not. Blood gases at arrest prior to resuscitation were comparable between groups. However, lambs that achieved ROSC had lower PaO2, higher PaCO2, and lower lactate during resuscitation. Increase in diastolic blood pressures induced by epinephrine in lambs that achieved ROSC (11 4 mmHg) did not differ from those that were not resuscitated (10+6 mmHg). Low diastolic blood pressures were adequate to achieve ROSC. Conclusions Hemodynamic parameters in a neonatal lamb asphyxia model with transitioning circulation did not predict success of ROSC. Lactic acidosis, higher PaO2 and lower PaCO2 observed in the lambs that did not achieve ROSC may represent a state of inadequate tissue perfusion and/or mitochondrial dysfunction.

Original languageEnglish (US)
Article numbere0176478
JournalPLoS One
Volume12
Issue number4
DOIs
StatePublished - Apr 1 2017

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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    Vali, P., Chandrasekharan, P., Rawat, M., Gugino, S., Koenigsknecht, C., Helman, J., Mathew, B., Berkelhamer, S., Nair, J., Wyckoff, M., & Lakshminrusimha, S. (2017). Hemodynamics and gas exchange during chest compressions in neonatal resuscitation. PLoS One, 12(4), [e0176478]. https://doi.org/10.1371/journal.pone.0176478