Abstract
Blood oxygenation level-dependent (BOLD) and cerebral blood flow (CBF)-based functional magnetic resonance imaging (fMRI) were used to measure primary visual cortex responses to photic stimulation in 23 children (12. 4 ± 0. 7 years old) with sickle cell anemia (SCA) and 21 clinical controls (11 ± 1. 0 years old). The objectives were to investigate the effect of SCA on detection of brain activation with fMRI and to explore the relationship between fMRI responses and global cognitive function. The BOLD responses were diminished in children with SCA. Clinical indicators of disease severity were greatest in patients without detectable visual cortex activation, but blood hemoglobin concentration and resting CBF were not predictive of BOLD signal amplitude in the SCA patients. Unexpectedly, the BOLD signal amplitude was positively associated (rs ≥ 0. 8, p ≤ 0. 05) with Wechsler Abbreviated Scale of Intelligence scores, suggesting that fMRI may help clarify medical, hemodynamic, and neural factors that mediate adverse effects of SCA on neurocognitive function.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 295-306 |
| Number of pages | 12 |
| Journal | Brain Imaging and Behavior |
| Volume | 5 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 2011 |
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Keywords
- Blood oxygenation level-dependent
- Brain activation
- Cerebral blood flow
- Cognitive function
- Functional magnetic resonance imaging
- Sickle cell anemia
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
- Neurology
- Cognitive Neuroscience
- Cellular and Molecular Neuroscience
- Behavioral Neuroscience
- Radiology Nuclear Medicine and imaging
Cite this
Hemodynamic responses to visual stimulation in children with sickle cell anemia. / Zou, Ping; Helton, Kathleen J.; Smeltzer, Matthew; Li, Chin-Shang; Conklin, Heather M.; Gajjar, Amar; Wang, Winfred C.; Ware, Russell E.; Ogg, Robert J.
In: Brain Imaging and Behavior, Vol. 5, No. 4, 12.2011, p. 295-306.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hemodynamic responses to visual stimulation in children with sickle cell anemia
AU - Zou, Ping
AU - Helton, Kathleen J.
AU - Smeltzer, Matthew
AU - Li, Chin-Shang
AU - Conklin, Heather M.
AU - Gajjar, Amar
AU - Wang, Winfred C.
AU - Ware, Russell E.
AU - Ogg, Robert J.
PY - 2011/12
Y1 - 2011/12
N2 - Blood oxygenation level-dependent (BOLD) and cerebral blood flow (CBF)-based functional magnetic resonance imaging (fMRI) were used to measure primary visual cortex responses to photic stimulation in 23 children (12. 4 ± 0. 7 years old) with sickle cell anemia (SCA) and 21 clinical controls (11 ± 1. 0 years old). The objectives were to investigate the effect of SCA on detection of brain activation with fMRI and to explore the relationship between fMRI responses and global cognitive function. The BOLD responses were diminished in children with SCA. Clinical indicators of disease severity were greatest in patients without detectable visual cortex activation, but blood hemoglobin concentration and resting CBF were not predictive of BOLD signal amplitude in the SCA patients. Unexpectedly, the BOLD signal amplitude was positively associated (rs ≥ 0. 8, p ≤ 0. 05) with Wechsler Abbreviated Scale of Intelligence scores, suggesting that fMRI may help clarify medical, hemodynamic, and neural factors that mediate adverse effects of SCA on neurocognitive function.
AB - Blood oxygenation level-dependent (BOLD) and cerebral blood flow (CBF)-based functional magnetic resonance imaging (fMRI) were used to measure primary visual cortex responses to photic stimulation in 23 children (12. 4 ± 0. 7 years old) with sickle cell anemia (SCA) and 21 clinical controls (11 ± 1. 0 years old). The objectives were to investigate the effect of SCA on detection of brain activation with fMRI and to explore the relationship between fMRI responses and global cognitive function. The BOLD responses were diminished in children with SCA. Clinical indicators of disease severity were greatest in patients without detectable visual cortex activation, but blood hemoglobin concentration and resting CBF were not predictive of BOLD signal amplitude in the SCA patients. Unexpectedly, the BOLD signal amplitude was positively associated (rs ≥ 0. 8, p ≤ 0. 05) with Wechsler Abbreviated Scale of Intelligence scores, suggesting that fMRI may help clarify medical, hemodynamic, and neural factors that mediate adverse effects of SCA on neurocognitive function.
KW - Blood oxygenation level-dependent
KW - Brain activation
KW - Cerebral blood flow
KW - Cognitive function
KW - Functional magnetic resonance imaging
KW - Sickle cell anemia
UR - http://www.scopus.com/inward/record.url?scp=80355146932&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80355146932&partnerID=8YFLogxK
U2 - 10.1007/s11682-011-9133-4
DO - 10.1007/s11682-011-9133-4
M3 - Article
C2 - 21881848
AN - SCOPUS:80355146932
VL - 5
SP - 295
EP - 306
JO - Brain Imaging and Behavior
JF - Brain Imaging and Behavior
SN - 1931-7557
IS - 4
ER -