Hemodynamic responses to visual stimulation in children with sickle cell anemia

Ping Zou; Kathleen J. Helton; Matthew Smeltzer; Chin-Shang Li; Heather M. Conklin; Amar Gajjar; Winfred C. Wang; Russell E. Ware; Robert J. Ogg

doi:10.1007/s11682-011-9133-4

Hemodynamic responses to visual stimulation in children with sickle cell anemia

Ping Zou, Kathleen J. Helton, Matthew Smeltzer, Chin-Shang Li, Heather M. Conklin, Amar Gajjar, Winfred C. Wang, Russell E. Ware, Robert J. Ogg

Public Health Sciences

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Blood oxygenation level-dependent (BOLD) and cerebral blood flow (CBF)-based functional magnetic resonance imaging (fMRI) were used to measure primary visual cortex responses to photic stimulation in 23 children (12. 4 ± 0. 7 years old) with sickle cell anemia (SCA) and 21 clinical controls (11 ± 1. 0 years old). The objectives were to investigate the effect of SCA on detection of brain activation with fMRI and to explore the relationship between fMRI responses and global cognitive function. The BOLD responses were diminished in children with SCA. Clinical indicators of disease severity were greatest in patients without detectable visual cortex activation, but blood hemoglobin concentration and resting CBF were not predictive of BOLD signal amplitude in the SCA patients. Unexpectedly, the BOLD signal amplitude was positively associated (r_s ≥ 0. 8, p ≤ 0. 05) with Wechsler Abbreviated Scale of Intelligence scores, suggesting that fMRI may help clarify medical, hemodynamic, and neural factors that mediate adverse effects of SCA on neurocognitive function.

Original language	English (US)
Pages (from-to)	295-306
Number of pages	12
Journal	Brain Imaging and Behavior
Volume	5
Issue number	4
DOIs	https://doi.org/10.1007/s11682-011-9133-4
State	Published - Dec 2011

Keywords

Blood oxygenation level-dependent
Brain activation
Cerebral blood flow
Cognitive function
Functional magnetic resonance imaging
Sickle cell anemia

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health
Neurology
Cognitive Neuroscience
Cellular and Molecular Neuroscience
Behavioral Neuroscience
Radiology Nuclear Medicine and imaging

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Hemodynamic responses to visual stimulation in children with sickle cell anemia. / Zou, Ping; Helton, Kathleen J.; Smeltzer, Matthew; Li, Chin-Shang; Conklin, Heather M.; Gajjar, Amar; Wang, Winfred C.; Ware, Russell E.; Ogg, Robert J.

In: Brain Imaging and Behavior, Vol. 5, No. 4, 12.2011, p. 295-306.

Research output: Contribution to journal › Article › peer-review

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abstract = "Blood oxygenation level-dependent (BOLD) and cerebral blood flow (CBF)-based functional magnetic resonance imaging (fMRI) were used to measure primary visual cortex responses to photic stimulation in 23 children (12. 4 ± 0. 7 years old) with sickle cell anemia (SCA) and 21 clinical controls (11 ± 1. 0 years old). The objectives were to investigate the effect of SCA on detection of brain activation with fMRI and to explore the relationship between fMRI responses and global cognitive function. The BOLD responses were diminished in children with SCA. Clinical indicators of disease severity were greatest in patients without detectable visual cortex activation, but blood hemoglobin concentration and resting CBF were not predictive of BOLD signal amplitude in the SCA patients. Unexpectedly, the BOLD signal amplitude was positively associated (rs ≥ 0. 8, p ≤ 0. 05) with Wechsler Abbreviated Scale of Intelligence scores, suggesting that fMRI may help clarify medical, hemodynamic, and neural factors that mediate adverse effects of SCA on neurocognitive function.",

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