Hemodynamic responses to visual stimulation in children with sickle cell anemia

Ping Zou, Kathleen J. Helton, Matthew Smeltzer, Chin-Shang Li, Heather M. Conklin, Amar Gajjar, Winfred C. Wang, Russell E. Ware, Robert J. Ogg

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Blood oxygenation level-dependent (BOLD) and cerebral blood flow (CBF)-based functional magnetic resonance imaging (fMRI) were used to measure primary visual cortex responses to photic stimulation in 23 children (12. 4 ± 0. 7 years old) with sickle cell anemia (SCA) and 21 clinical controls (11 ± 1. 0 years old). The objectives were to investigate the effect of SCA on detection of brain activation with fMRI and to explore the relationship between fMRI responses and global cognitive function. The BOLD responses were diminished in children with SCA. Clinical indicators of disease severity were greatest in patients without detectable visual cortex activation, but blood hemoglobin concentration and resting CBF were not predictive of BOLD signal amplitude in the SCA patients. Unexpectedly, the BOLD signal amplitude was positively associated (rs ≥ 0. 8, p ≤ 0. 05) with Wechsler Abbreviated Scale of Intelligence scores, suggesting that fMRI may help clarify medical, hemodynamic, and neural factors that mediate adverse effects of SCA on neurocognitive function.

Original languageEnglish (US)
Pages (from-to)295-306
Number of pages12
JournalBrain Imaging and Behavior
Issue number4
StatePublished - Dec 2011


  • Blood oxygenation level-dependent
  • Brain activation
  • Cerebral blood flow
  • Cognitive function
  • Functional magnetic resonance imaging
  • Sickle cell anemia

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience
  • Behavioral Neuroscience
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Hemodynamic responses to visual stimulation in children with sickle cell anemia'. Together they form a unique fingerprint.

Cite this