Hemodynamic effects of dexmedetomidine, with and without MK-467, following intramuscular administration in cats anesthetized with isoflurane

Kristine T. Siao, Bruno H Pypendop, Juhana Honkavaara, Jan Ilkiw

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective To characterize the hemodynamic effects of dexmedetomidine, with or without MK-467, following intramuscular (IM) administration in cats. Study design Randomized, crossover, experimental study. Animals Six healthy adult male castrated purpose-bred cats. Methods Cats were anesthetized with isoflurane in oxygen and instrumented. Cats were administered dexmedetomidine (25 μg kg−1), with (DM) or without (D) MK-467 (600 μg kg−1), IM in the epaxial muscles. Cardiovascular variables, respiratory variables, temperature, and arterial and mixed-venous pH, blood gases and electrolytes were measured prior to drug administration and at various time points for 6 hours thereafter, during anesthesia with isoflurane. Additional variables were calculated from the measurements, using standard equations. Results were analyzed with a two-way repeated-measures analysis of variance, followed by Dunnett's and paired t tests where appropriate. Results Dexmedetomidine resulted in a significant decrease in cardiac index (CI) and significant increases in mean arterial pressure (MAP) and systemic vascular resistance index (SVRI). The addition of MK-467 failed to prevent most of the early cardiovascular effects of dexmedetomidine, but the duration of systemic vasoconstriction was shorter and CI did not decrease. The lowest and highest post-treatment values in each treatment were 0.1 ± 0.03 and 0.13 ± 0.03 L minute−1 BW−0.67 (D) versus 0.14 ± 0.01 and 0.19 ± 0.03 L minute−1 BW−0.67 (DM) for CI, 87 ± 13 and 181 ± 21 mmHg (D) versus 70 ± 11 and 153 ± 18 mmHg (DM) for MAP and 58,948 ± 17,754 and 119,432 ± 40,423 dynes second cm−5 BW−0.67 (D) versus 25,870 ± 3782 and 76,498 ± 17,258 dynes second cm−5 BW−0.67 (DM) for SVRI, respectively. Conclusion and clinical relevance IM coadministration of MK-467 and dexmedetomidine in isoflurane-anesthetized cats shortened dexmedetomidine-induced cardiovascular effects. This drug combination may be useful in cats in which longer-lasting hypertension and hemodynamic depression is of concern.

Original languageEnglish (US)
Pages (from-to)1101-1115
Number of pages15
JournalVeterinary Anaesthesia and Analgesia
Volume44
Issue number5
DOIs
StatePublished - Sep 1 2017

Fingerprint

L 659066
dexmedetomidine
Dexmedetomidine
Isoflurane
isoflurane
hemodynamics
intramuscular injection
Cats
Hemodynamics
cats
blood vessels
Vascular Resistance
Arterial Pressure
combination drug therapy
vasoconstriction
blood gases
Drug Combinations
Vasoconstriction
Cross-Over Studies
Electrolytes

Keywords

  • antagonist
  • cardiopulmonary
  • cat
  • dexmedetomidine
  • α-agonist

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Hemodynamic effects of dexmedetomidine, with and without MK-467, following intramuscular administration in cats anesthetized with isoflurane. / Siao, Kristine T.; Pypendop, Bruno H; Honkavaara, Juhana; Ilkiw, Jan.

In: Veterinary Anaesthesia and Analgesia, Vol. 44, No. 5, 01.09.2017, p. 1101-1115.

Research output: Contribution to journalArticle

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abstract = "Objective To characterize the hemodynamic effects of dexmedetomidine, with or without MK-467, following intramuscular (IM) administration in cats. Study design Randomized, crossover, experimental study. Animals Six healthy adult male castrated purpose-bred cats. Methods Cats were anesthetized with isoflurane in oxygen and instrumented. Cats were administered dexmedetomidine (25 μg kg−1), with (DM) or without (D) MK-467 (600 μg kg−1), IM in the epaxial muscles. Cardiovascular variables, respiratory variables, temperature, and arterial and mixed-venous pH, blood gases and electrolytes were measured prior to drug administration and at various time points for 6 hours thereafter, during anesthesia with isoflurane. Additional variables were calculated from the measurements, using standard equations. Results were analyzed with a two-way repeated-measures analysis of variance, followed by Dunnett's and paired t tests where appropriate. Results Dexmedetomidine resulted in a significant decrease in cardiac index (CI) and significant increases in mean arterial pressure (MAP) and systemic vascular resistance index (SVRI). The addition of MK-467 failed to prevent most of the early cardiovascular effects of dexmedetomidine, but the duration of systemic vasoconstriction was shorter and CI did not decrease. The lowest and highest post-treatment values in each treatment were 0.1 ± 0.03 and 0.13 ± 0.03 L minute−1 BW−0.67 (D) versus 0.14 ± 0.01 and 0.19 ± 0.03 L minute−1 BW−0.67 (DM) for CI, 87 ± 13 and 181 ± 21 mmHg (D) versus 70 ± 11 and 153 ± 18 mmHg (DM) for MAP and 58,948 ± 17,754 and 119,432 ± 40,423 dynes second cm−5 BW−0.67 (D) versus 25,870 ± 3782 and 76,498 ± 17,258 dynes second cm−5 BW−0.67 (DM) for SVRI, respectively. Conclusion and clinical relevance IM coadministration of MK-467 and dexmedetomidine in isoflurane-anesthetized cats shortened dexmedetomidine-induced cardiovascular effects. This drug combination may be useful in cats in which longer-lasting hypertension and hemodynamic depression is of concern.",
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T1 - Hemodynamic effects of dexmedetomidine, with and without MK-467, following intramuscular administration in cats anesthetized with isoflurane

AU - Siao, Kristine T.

AU - Pypendop, Bruno H

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AU - Ilkiw, Jan

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N2 - Objective To characterize the hemodynamic effects of dexmedetomidine, with or without MK-467, following intramuscular (IM) administration in cats. Study design Randomized, crossover, experimental study. Animals Six healthy adult male castrated purpose-bred cats. Methods Cats were anesthetized with isoflurane in oxygen and instrumented. Cats were administered dexmedetomidine (25 μg kg−1), with (DM) or without (D) MK-467 (600 μg kg−1), IM in the epaxial muscles. Cardiovascular variables, respiratory variables, temperature, and arterial and mixed-venous pH, blood gases and electrolytes were measured prior to drug administration and at various time points for 6 hours thereafter, during anesthesia with isoflurane. Additional variables were calculated from the measurements, using standard equations. Results were analyzed with a two-way repeated-measures analysis of variance, followed by Dunnett's and paired t tests where appropriate. Results Dexmedetomidine resulted in a significant decrease in cardiac index (CI) and significant increases in mean arterial pressure (MAP) and systemic vascular resistance index (SVRI). The addition of MK-467 failed to prevent most of the early cardiovascular effects of dexmedetomidine, but the duration of systemic vasoconstriction was shorter and CI did not decrease. The lowest and highest post-treatment values in each treatment were 0.1 ± 0.03 and 0.13 ± 0.03 L minute−1 BW−0.67 (D) versus 0.14 ± 0.01 and 0.19 ± 0.03 L minute−1 BW−0.67 (DM) for CI, 87 ± 13 and 181 ± 21 mmHg (D) versus 70 ± 11 and 153 ± 18 mmHg (DM) for MAP and 58,948 ± 17,754 and 119,432 ± 40,423 dynes second cm−5 BW−0.67 (D) versus 25,870 ± 3782 and 76,498 ± 17,258 dynes second cm−5 BW−0.67 (DM) for SVRI, respectively. Conclusion and clinical relevance IM coadministration of MK-467 and dexmedetomidine in isoflurane-anesthetized cats shortened dexmedetomidine-induced cardiovascular effects. This drug combination may be useful in cats in which longer-lasting hypertension and hemodynamic depression is of concern.

AB - Objective To characterize the hemodynamic effects of dexmedetomidine, with or without MK-467, following intramuscular (IM) administration in cats. Study design Randomized, crossover, experimental study. Animals Six healthy adult male castrated purpose-bred cats. Methods Cats were anesthetized with isoflurane in oxygen and instrumented. Cats were administered dexmedetomidine (25 μg kg−1), with (DM) or without (D) MK-467 (600 μg kg−1), IM in the epaxial muscles. Cardiovascular variables, respiratory variables, temperature, and arterial and mixed-venous pH, blood gases and electrolytes were measured prior to drug administration and at various time points for 6 hours thereafter, during anesthesia with isoflurane. Additional variables were calculated from the measurements, using standard equations. Results were analyzed with a two-way repeated-measures analysis of variance, followed by Dunnett's and paired t tests where appropriate. Results Dexmedetomidine resulted in a significant decrease in cardiac index (CI) and significant increases in mean arterial pressure (MAP) and systemic vascular resistance index (SVRI). The addition of MK-467 failed to prevent most of the early cardiovascular effects of dexmedetomidine, but the duration of systemic vasoconstriction was shorter and CI did not decrease. The lowest and highest post-treatment values in each treatment were 0.1 ± 0.03 and 0.13 ± 0.03 L minute−1 BW−0.67 (D) versus 0.14 ± 0.01 and 0.19 ± 0.03 L minute−1 BW−0.67 (DM) for CI, 87 ± 13 and 181 ± 21 mmHg (D) versus 70 ± 11 and 153 ± 18 mmHg (DM) for MAP and 58,948 ± 17,754 and 119,432 ± 40,423 dynes second cm−5 BW−0.67 (D) versus 25,870 ± 3782 and 76,498 ± 17,258 dynes second cm−5 BW−0.67 (DM) for SVRI, respectively. Conclusion and clinical relevance IM coadministration of MK-467 and dexmedetomidine in isoflurane-anesthetized cats shortened dexmedetomidine-induced cardiovascular effects. This drug combination may be useful in cats in which longer-lasting hypertension and hemodynamic depression is of concern.

KW - antagonist

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KW - dexmedetomidine

KW - α-agonist

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