TY - JOUR
T1 - Hemodynamic and serum biochemical alterations associated with intravenous administration of three types of contrast media in anesthetized cats
AU - Pollard, Rachel E
AU - Puchalski, Sarah M.
AU - Pascoe, Peter J
PY - 2008/10
Y1 - 2008/10
N2 - Objective - To determine the incidence and type of alterations in heart rate (HR), peak systolic blood pressure (PSBP), and serum biochemical variables (serum total bilirubin, BUN, and creatinine concentrations) associated with IV administration of ionic-iodinated contrast (IIC), nonionic-iodinated contrast (NIC), and gadolinium (GD) contrast media in anesthetized cats. Animals - 220 anesthetized cats undergoing cross-sectional imaging. Procedures - HR and PSBP were recorded at 5-minute intervals for 20 minutes for untreated control cats and cats that received IIC, NIC, or GD contrast medium. The development of HR < 100 beats/min or > 200 beats/min that included a ≥ 20% change from baseline was considered a response. The development of PSBP of < 90 mm Hg or > 170 mm Hg that included a ≥ 20% change from baseline was considered a response. Pre- and postcontrast serum biochemical values were recorded. Results - Of cats receiving IIC medium, 2% (1/60) had a response in HR at ≥ 1 time point. Of cats receiving IIC medium, 7% (4/60) had a response in PSBP. None of the cats receiving NIC medium had a response in HR; 2 of 12 had a response in PSBP. Of cats receiving GD contrast medium, 6% (5/83) had a response in HR and 8% (7/83) had a response in PSBP. None of the control cats had a response in HR or PSBP. No serum biochemical alterations were observed. Conclusions and Clinical Relevance - IV administration of iodine and GD contrast media in anesthetized cats was associated with changes in HR and PSBP.
AB - Objective - To determine the incidence and type of alterations in heart rate (HR), peak systolic blood pressure (PSBP), and serum biochemical variables (serum total bilirubin, BUN, and creatinine concentrations) associated with IV administration of ionic-iodinated contrast (IIC), nonionic-iodinated contrast (NIC), and gadolinium (GD) contrast media in anesthetized cats. Animals - 220 anesthetized cats undergoing cross-sectional imaging. Procedures - HR and PSBP were recorded at 5-minute intervals for 20 minutes for untreated control cats and cats that received IIC, NIC, or GD contrast medium. The development of HR < 100 beats/min or > 200 beats/min that included a ≥ 20% change from baseline was considered a response. The development of PSBP of < 90 mm Hg or > 170 mm Hg that included a ≥ 20% change from baseline was considered a response. Pre- and postcontrast serum biochemical values were recorded. Results - Of cats receiving IIC medium, 2% (1/60) had a response in HR at ≥ 1 time point. Of cats receiving IIC medium, 7% (4/60) had a response in PSBP. None of the cats receiving NIC medium had a response in HR; 2 of 12 had a response in PSBP. Of cats receiving GD contrast medium, 6% (5/83) had a response in HR and 8% (7/83) had a response in PSBP. None of the control cats had a response in HR or PSBP. No serum biochemical alterations were observed. Conclusions and Clinical Relevance - IV administration of iodine and GD contrast media in anesthetized cats was associated with changes in HR and PSBP.
UR - http://www.scopus.com/inward/record.url?scp=56049108833&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=56049108833&partnerID=8YFLogxK
U2 - 10.2460/ajvr.69.10.1274
DO - 10.2460/ajvr.69.10.1274
M3 - Article
C2 - 18828682
AN - SCOPUS:56049108833
VL - 69
SP - 1274
EP - 1278
JO - American Journal of Veterinary Research
JF - American Journal of Veterinary Research
SN - 0002-9645
IS - 10
ER -