Hemispheric asymmetries in cortical and subcortical anatomy

Xiaojian Kang, Timothy J. Herron, Marc Ettlinger, David L Woods

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Previous research studies have reported many hemispherical asymmetries in cortical and subcortical anatomy, but only a subset of findings is consistent across studies. Here, we used improved Freesurfer-based automated methods to analyse the properties of the cortex and seven subcortical structures in 138 young adult subjects. Male and female subjects showed similar hemispheric asymmetries in gyral and sulcal structures, with many areas associated with language processing enlarged in the left hemisphere (LH) and a number of areas associated with visuospatial processing enlarged in the right hemisphere (RH). In addition, we found greater (non-directional) cortical asymmetries in subjects with larger brains. Asymmetries in subcortical structures included larger LH volumes of thalamus, putamen and globus pallidus and larger RH volumes of the cerebellum and the amygdala. We also found significant correlations between the subcortical structural volumes, particularly of the thalamus and cerebellum, with cortical area. These results help to resolve some of the inconsistencies in previous studies of hemispheric asymmetries in brain anatomy.

Original languageEnglish (US)
Pages (from-to)658-684
Number of pages27
Issue number6
StatePublished - Nov 2 2015


  • Frontal
  • Insula
  • Occipital
  • Parietal
  • Temporal

ASJC Scopus subject areas

  • Psychology(all)
  • Arts and Humanities (miscellaneous)


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