Heme oxygenase inhibitors transiently increase serum ferritin concentrations without altering other acute-phase reactants in man

Lars Berglund, Richard A. Galbraith, Lennart Emtestam, George S. Drummond, Bo Angelin, Attallah Kappas

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Sn protoporphyrin (SnPP) and Sn mesoporphyrin (SnMP), potent inhibitors of heme oxygenase (HO), significantly suppress bilirubin production, lower serum and biliary bilirubin levels and increase biliary heme output in animals and man. In this study, 20 healthy volunteers, 7 patients with primary biliary cirrhosis and 4 patients with idiopathic hemochromatosis were treated with SnPP and 4 healthy volunteers with SnMP. In all cases, serum ferritin levels increased substantially but transiently after administration of these HO inhibitors. Values returned to baseline within a few days. Infusion of hematin in 4 healthy volunteers did not significantly affect ferritin levels. No increases occurred in 7 other acute-phase reactants. The observation that these HO inhibitors transiently increase serum ferritin levels implies a link between ferritin, iron metabolism and HO activity which may be usefully explored in disorders of iron metabolism.

Original languageEnglish (US)
Pages (from-to)51-56
Number of pages6
JournalPharmacology
Volume59
Issue number1
DOIs
StatePublished - Jul 1999
Externally publishedYes

Keywords

  • Bilirubin
  • Ferritin
  • Heme
  • Heme oxygenase inhibitors
  • Iron metabolism

ASJC Scopus subject areas

  • Pharmacology

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