Hematopoietic cell transplants in autoimmunity

Jozélio Freire De Carvalho, Rosa Maria Rodrigues Pereira, M. Eric Gershwin

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Approximately 1 in 31 people suffers from an autoimmune disease. The clinical care of patients with autoimmunity crosses multiple disciplines within pediatrics and internal medicine, including, for example, allergy-clinical immunology, rheumatology, nephrology, hematology, pulmonology and neurology. There are two major areas that are considered in the analysis of autoimmunity in human patients. The first of course is etiology and the second, and of even greater importance, is therapy. Towards that end, considerable attention has focused on the role of hematopoietic stem cell transplantation to either reverse or modulate autoimmune disease. Indeed, it is a field that has far more promise than premise based on a variety of issues, including economics, health care delivery, and obviously efficacy and safety. To put this in perspective, we have attempted to review some of the issues that pertain to this novel approach to the management of autoimmunity. Finally, we emphasize the need to incorporate basic research into therapeutic trials, a vacuum all too often present in clinical intervention.

Original languageEnglish (US)
Pages (from-to)629-632
Number of pages4
JournalIsrael Medical Association Journal
Issue number10
StatePublished - Oct 2009


  • Autoimmune diseases
  • Hematopoietic cell transplant
  • Refractory diseases
  • Stem cell transpalntation
  • Treatment

ASJC Scopus subject areas

  • Medicine(all)


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