Hematopoiesis on cellulose ester membranes (CEM). V. Enrichment of CEM by demineralized mouse bone matrix powder

W. H. Knospe, S. G. Husseini, S. S. Adler, A Hari Reddi

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Mouse bone matrix powder was implanted subcutaneously or put into folded tubular cellulose ester membranes (CEM) and implanted i.p. Calcification and new bone formation did not develop. Sinusoidal vascularization of the matrix developed by 3 to 4 wk. Stromal cells such as fat cells and fibroblasts were present by 4 wk. Hematopoiesis was absent except for rare foci of granulopoiesis on some of the CEM at 6 wk. Rat bone matrix implanted subcutaneously into mice and mouse bone matrix implanted subcutaneously into rats failed to induce new bone formation or hematopoiesis.

Original languageEnglish (US)
Pages (from-to)1021-1026
Number of pages6
JournalExperimental Hematology
Volume11
Issue number10
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Genetics
  • Hematology
  • Oncology
  • Transplantation

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