Hematological Disorders Following Bariatric Surgery

H. Qiu, Ralph Green, M. Chen

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Bariatric surgery is a highly effective therapy for morbidly obese patients. Roux-en-Y gastric bypass (RYGB) is usually the most common bariatric surgery procedure performed worldwide. It not only produces significant and durable weight loss, but also results in improvement of obesity-related comorbidities. However, the major problems related to this surgery are nutritional deficiencies and chronic hematological complications, like anemias pertaining to anatomical and associated physiological alteration of the gastrointestinal tract. Anemia after RYGB has been associated with insufficient intake and malabsorption of micronutrients such as iron, vitamin B12, folate, and copper concomitantly with obesity-mediated chronic inflammatory anemia. The crosstalk between chronic inflammation, immune dysregulation, and long-term sequelae of nutritional deficiency may lead to a complex suppression of normal hematopoiesis, manifested as persistent anemia only partially responsive (or nonresponsive) to nutritional supplementation. Clinical follow-up and early diagnosis are essential to allow appropriate intervention before potentially irreversible clinical manifestations occur.

Original languageEnglish (US)
Title of host publicationMetabolism and Pathophysiology of Bariatric Surgery
Subtitle of host publicationNutrition, Procedures, Outcomes and Adverse Effects
PublisherElsevier Inc.
Pages351-360
Number of pages10
ISBN (Electronic)9780128040638
ISBN (Print)9780128040119
DOIs
StatePublished - Dec 16 2016

Fingerprint

Bariatric Surgery
Anemia
Gastric Bypass
Malnutrition
Obesity
Micronutrients
Hematopoiesis
Vitamin B 12
Folic Acid
Gastrointestinal Tract
Comorbidity
Weight Loss
Copper
Early Diagnosis
Iron
Inflammation
Therapeutics

Keywords

  • Anemia
  • Anemia of inflammation
  • Copper deficiency
  • Folate deficiency
  • Gastric bypass surgery
  • Iron deficiency
  • Vitamin B12 deficiency

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Qiu, H., Green, R., & Chen, M. (2016). Hematological Disorders Following Bariatric Surgery. In Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes and Adverse Effects (pp. 351-360). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-804011-9.00046-7

Hematological Disorders Following Bariatric Surgery. / Qiu, H.; Green, Ralph; Chen, M.

Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes and Adverse Effects. Elsevier Inc., 2016. p. 351-360.

Research output: Chapter in Book/Report/Conference proceedingChapter

Qiu, H, Green, R & Chen, M 2016, Hematological Disorders Following Bariatric Surgery. in Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes and Adverse Effects. Elsevier Inc., pp. 351-360. https://doi.org/10.1016/B978-0-12-804011-9.00046-7
Qiu H, Green R, Chen M. Hematological Disorders Following Bariatric Surgery. In Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes and Adverse Effects. Elsevier Inc. 2016. p. 351-360 https://doi.org/10.1016/B978-0-12-804011-9.00046-7
Qiu, H. ; Green, Ralph ; Chen, M. / Hematological Disorders Following Bariatric Surgery. Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes and Adverse Effects. Elsevier Inc., 2016. pp. 351-360
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