Hematological and biochemical laboratory values in older cardiovascular health study participants

John A Robbins, P. Wahl, P. Savage, P. Enright, N. Powe, M. Lyles

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


OBJECTIVE: To define reference hematologic and biochemical lab values in older individuals. DESIGN: Randomly selected, age- and gender-stratified participants. SETTING: Visits by participants to four research clinics. PATIENTS: A total of 5201 participants in the Cardiovascular Health Study, an observational study of older Medicare-eligible individuals living at home. MEASUREMENT: Information about health status, previous illness, and medication use was obtained from participants and/or their MDs. This information was used to define a healthy subset of the population. Blood samples were obtained for Cholesterol, HDL and LDL cholesterol, fasting and 2-hour postload glucose and insulin, fibrinogen, factors VII and VIII, potassium, creatinine, albumin, uric acid, white blood count, hematocrit, hemoglobin, and platelet count. RESULTS: Significant differences were found for age group and/or gender for all mean values. Many tests were significantly different from the generally accepted reference ranges used in clinical laboratories. CONCLUSIONS: In some situations accepted laboratory norms for the general population can not be extrapolated to older adults. There are implications for both research and clinical practice.

Original languageEnglish (US)
Pages (from-to)855-859
Number of pages5
JournalJournal of the American Geriatrics Society
Issue number8
StatePublished - 1995

ASJC Scopus subject areas

  • Geriatrics and Gerontology


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