Hematologic abnormalities in simian acquired immune deficiency syndrome

M. MacKenzie, Linda J Lowenstine, R. Lalchandani, N. Lerche, K. Osborn, A. Spinner, M. Bleviss, R. Hendrickson, M. Gardner

Research output: Chapter in Book/Report/Conference proceedingChapter

18 Citations (Scopus)

Abstract

Hematologic abnormalities were defined in 31 rhesus monkeys (Macaca mulatta) with simian acquired immune deficiency syndrome (SAIDS). Animals manifested anemia (hypochromic/microcytic), severe neutropenia and progressive lymphopenia, monocytosis and occasional thrombocytopenia. Bone marrow studies showed erythroid hyperplasia with a marked left shift and adequate megakaryocytes. Two animals showed profound hypoplasia of all hematopoietic elements. Most animals were iron deficient, but the course of the anemia suggested additional factors. There was no evidence of immune hemolysis. The pathogenesis of these abnormalities is not clear and will require further study. This reproducible disease will allow studies to elucidate the mechanisms of viral-induced hematologic abnormalities.

Original languageEnglish (US)
Title of host publicationLaboratory Animal Science
Pages14-19
Number of pages6
Volume36
Edition1
StatePublished - 1986

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Simian Acquired Immunodeficiency Syndrome
Macaca mulatta
Lymphopenia
Megakaryocytes
Hemolysis
Neutropenia
Thrombocytopenia
Hyperplasia
Anemia
Iron
Bone Marrow

ASJC Scopus subject areas

  • Medicine(all)

Cite this

MacKenzie, M., Lowenstine, L. J., Lalchandani, R., Lerche, N., Osborn, K., Spinner, A., ... Gardner, M. (1986). Hematologic abnormalities in simian acquired immune deficiency syndrome. In Laboratory Animal Science (1 ed., Vol. 36, pp. 14-19)

Hematologic abnormalities in simian acquired immune deficiency syndrome. / MacKenzie, M.; Lowenstine, Linda J; Lalchandani, R.; Lerche, N.; Osborn, K.; Spinner, A.; Bleviss, M.; Hendrickson, R.; Gardner, M.

Laboratory Animal Science. Vol. 36 1. ed. 1986. p. 14-19.

Research output: Chapter in Book/Report/Conference proceedingChapter

MacKenzie, M, Lowenstine, LJ, Lalchandani, R, Lerche, N, Osborn, K, Spinner, A, Bleviss, M, Hendrickson, R & Gardner, M 1986, Hematologic abnormalities in simian acquired immune deficiency syndrome. in Laboratory Animal Science. 1 edn, vol. 36, pp. 14-19.
MacKenzie M, Lowenstine LJ, Lalchandani R, Lerche N, Osborn K, Spinner A et al. Hematologic abnormalities in simian acquired immune deficiency syndrome. In Laboratory Animal Science. 1 ed. Vol. 36. 1986. p. 14-19
MacKenzie, M. ; Lowenstine, Linda J ; Lalchandani, R. ; Lerche, N. ; Osborn, K. ; Spinner, A. ; Bleviss, M. ; Hendrickson, R. ; Gardner, M. / Hematologic abnormalities in simian acquired immune deficiency syndrome. Laboratory Animal Science. Vol. 36 1. ed. 1986. pp. 14-19
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