Helper roles of NK and CD8+ T cells in the induction of tumor immunity: Polarized dendritic cells as cancer vaccines

Pawel Kalinski, Yutaro Nakamura, Payal Watchmaker, Adam Giermasz, Ravikumar Muthuswamy, Robbie B. Mailliard

Research output: Contribution to journalReview article

55 Scopus citations

Abstract

The work in our laboratory addresses two interrelated areas of dendritic cell (DC) biology: (1) the role of DCs as mediators of feedback interactions between NK cells, CD8+ and CD4+ T cells; and (2) the possibility to use such feedback and the paradigms derived from anti-viral responses, to promote the induction of therapeutic immunity against cancer. We observed that CD8+ T cells and NK cells, the classical "effector" cells, also play "helper" roles, regulating ability of DCs to induce type-1 immune immunity, critical for fighting tumors and intracellular pathogens. Our work aims to delineate which pathways of NK and CD8+ T cell activation result in their helper activity, and to identify the molecular mechanisms allowing them to induce type-1 polarized DCs (DC1s) with selectively enhanced ability to promote type-1 responses and anti-cancer immunity. The results of these studies allowed us and our colleagues to design phase I/II clinical trials incorporating the paradigms of DC polarization and helper activity of effector cells in cancer immunotherapy.

Original languageEnglish (US)
Pages (from-to)137-146
Number of pages10
JournalImmunologic Research
Volume36
Issue number1-3
StatePublished - Sep 2006
Externally publishedYes

Keywords

  • Cancer
  • Clinical trials
  • Colorectal cancer
  • CTL
  • Dendric cells
  • Immunotherapy
  • Melanoma
  • NK cells
  • Prostate cancer
  • Th1
  • Vaccines

ASJC Scopus subject areas

  • Immunology

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    Kalinski, P., Nakamura, Y., Watchmaker, P., Giermasz, A., Muthuswamy, R., & Mailliard, R. B. (2006). Helper roles of NK and CD8+ T cells in the induction of tumor immunity: Polarized dendritic cells as cancer vaccines. Immunologic Research, 36(1-3), 137-146.