Helix packing in polytopic membrane proteins: The lactose permease of Escherichia coli

H. Ronald Kaback, John C Voss, Jianhua Wu

Research output: Contribution to journalArticle

88 Scopus citations


Recent advances in protein engineering have facilitated the development of alternative approaches to determine helix packing in polytopic membrane proteins. Using the lac permease as a paradigm, several site-directed biophysical and biochemical techniques are described which should be generally applicable.

Original languageEnglish (US)
Pages (from-to)537-542
Number of pages6
JournalCurrent Opinion in Structural Biology
Issue number4
StatePublished - Aug 1997
Externally publishedYes


ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

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