Helicobacter pylori and migraine

Systematic evaluation of 1084 cases with meta-analysis

Nirmal S Mann, Sital Singh

Research output: Contribution to journalArticle

Abstract

Objectives: Helicobacter pylori (HP) is a gram-negative organism, which can cause gastritis, peptic ulcer disease, gastric lymphoma and gastric cancer. It has also been implicated in conditions such as coronary artery disease, short stature, iron deficiency anemia, hypertension, cerebral ischemia and migraine (MGR). The association of HP with MGR is controversial. We reviewed the literature on HP and migraine and performed a meta-analysis (QMA) on these cases. Methods: PubMed search for H. pylori and migraine was performed without time or language barriers. QMA was performed using the well-established methods of Qualitative Research e.g. Diagramming, Theme Repetition without Serious Contradiction, Theme Saturation and investigator Reflexivity. To facilitate QMA, summary sheets of publications were prepared. Results: The PubMEd search yielded 1084 cases of Migraine associated with HP. Information about gender was available in 48.4%. These included 65.4% women and 34.6% men. The possible mechanisms were vascular instability, production of histamine, oxidative stress and generation of nitric oxide. In some studies elimination of HP resulted in amelioration of MGR symptoms. HP was associated with both MGR with aura and MGR without aura. However, some investigators failed to show an association of MGR with HP. Conclusion: There are strong indications regarding the association between HP and MGR. Larger prospective case-control studies are needed to settle this issue.

Original languageEnglish (US)
Pages (from-to)65-66
Number of pages2
JournalInternational Medical Journal
Volume22
Issue number2
StatePublished - 2015

Fingerprint

Migraine Disorders
Helicobacter pylori
Meta-Analysis
PubMed
Research Personnel
Communication Barriers
Migraine without Aura
Migraine with Aura
Iron-Deficiency Anemias
Qualitative Research
Gastritis
Brain Ischemia
Peptic Ulcer
Histamine
Stomach Neoplasms
Blood Vessels
Publications
Case-Control Studies
Coronary Artery Disease
Nitric Oxide

Keywords

  • H. pylori
  • Meta-analysis
  • Migraine
  • Vascular instability

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Helicobacter pylori and migraine : Systematic evaluation of 1084 cases with meta-analysis. / Mann, Nirmal S; Singh, Sital.

In: International Medical Journal, Vol. 22, No. 2, 2015, p. 65-66.

Research output: Contribution to journalArticle

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