Heightened cytotoxic responses and impaired biogenesis contribute to early pathogenesis in the oral mucosa of simian immunodeficiency virus-infected rhesus macaques

Michael D. George; David Verhoeven; Sumathi Sankaran-Walters; Tiffany Glavan; Elizabeth Reay; Satya Dandekar

doi:10.1128/CVI.00265-08

Heightened cytotoxic responses and impaired biogenesis contribute to early pathogenesis in the oral mucosa of simian immunodeficiency virus-infected rhesus macaques

Michael D. George, David Verhoeven, Sumathi Sankaran-Walters, Tiffany Glavan, Elizabeth Reay, Satya Dandekar

Medical Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Simian immunodeficiency virus (SIV) infection disseminated into the oropharyngeal tissues of rhesus macaques 6 weeks following intravenous inoculation. Severe local CD4 ⁺ T-cell depletion coincided with increases in NK cell and proinflammatory biomarkers and the disruption of growth-associated gene transcription, demonstrating the rapid establishment of pathogenesis in the oral mucosa.

Original language	English (US)
Pages (from-to)	277-281
Number of pages	5
Journal	Clinical and Vaccine Immunology
Volume	16
Issue number	2
DOIs	https://doi.org/10.1128/CVI.00265-08
State	Published - Feb 2009

ASJC Scopus subject areas

Clinical Biochemistry
Immunology
Immunology and Allergy
Microbiology (medical)

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Heightened cytotoxic responses and impaired biogenesis contribute to early pathogenesis in the oral mucosa of simian immunodeficiency virus-infected rhesus macaques. / George, Michael D.; Verhoeven, David; Sankaran-Walters, Sumathi; Glavan, Tiffany; Reay, Elizabeth; Dandekar, Satya.

In: Clinical and Vaccine Immunology, Vol. 16, No. 2, 02.2009, p. 277-281.

Research output: Contribution to journal › Article › peer-review

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Heightened cytotoxic responses and impaired biogenesis contribute to early pathogenesis in the oral mucosa of simian immunodeficiency virus-infected rhesus macaques

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