Heightened cytotoxic responses and impaired biogenesis contribute to early pathogenesis in the oral mucosa of simian immunodeficiency virus-infected rhesus macaques

Michael D. George, David Verhoeven, Sumathi Sankaran-Walters, Tiffany Glavan, Elizabeth Reay, Satya Dandekar

Research output: Contribution to journal › Article

5 Citations (Scopus)

Abstract

Simian immunodeficiency virus (SIV) infection disseminated into the oropharyngeal tissues of rhesus macaques 6 weeks following intravenous inoculation. Severe local CD4 + T-cell depletion coincided with increases in NK cell and proinflammatory biomarkers and the disruption of growth-associated gene transcription, demonstrating the rapid establishment of pathogenesis in the oral mucosa.

Original languageEnglish (US)
Pages (from-to)277-281
Number of pages5
JournalClinical and Vaccine Immunology
Volume16
Issue number2
DOIs
StatePublished - Feb 2009

Fingerprint

Simian Immunodeficiency Virus
T-cells
Mouth Mucosa
Biomarkers
Virus Diseases
Transcription
Macaca mulatta
Viruses
Natural Killer Cells
Genes
Tissue
T-Lymphocytes
Growth
Mucous Membrane

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Immunology
  • Immunology and Allergy
  • Microbiology (medical)

Cite this

Heightened cytotoxic responses and impaired biogenesis contribute to early pathogenesis in the oral mucosa of simian immunodeficiency virus-infected rhesus macaques. / George, Michael D.; Verhoeven, David; Sankaran-Walters, Sumathi; Glavan, Tiffany; Reay, Elizabeth; Dandekar, Satya.

In: Clinical and Vaccine Immunology, Vol. 16, No. 2, 02.2009, p. 277-281.

Research output: Contribution to journal › Article

George, MD, Verhoeven, D, Sankaran-Walters, S, Glavan, T, Reay, E & Dandekar, S 2009, 'Heightened cytotoxic responses and impaired biogenesis contribute to early pathogenesis in the oral mucosa of simian immunodeficiency virus-infected rhesus macaques', Clinical and Vaccine Immunology, vol. 16, no. 2, pp. 277-281. https://doi.org/10.1128/CVI.00265-08
George MD, Verhoeven D, Sankaran-Walters S, Glavan T, Reay E, Dandekar S. Heightened cytotoxic responses and impaired biogenesis contribute to early pathogenesis in the oral mucosa of simian immunodeficiency virus-infected rhesus macaques. Clinical and Vaccine Immunology. 2009 Feb;16(2):277-281. https://doi.org/10.1128/CVI.00265-08
George, Michael D. ; Verhoeven, David ; Sankaran-Walters, Sumathi ; Glavan, Tiffany ; Reay, Elizabeth ; Dandekar, Satya. / Heightened cytotoxic responses and impaired biogenesis contribute to early pathogenesis in the oral mucosa of simian immunodeficiency virus-infected rhesus macaques. In: Clinical and Vaccine Immunology. 2009 ; Vol. 16, No. 2. pp. 277-281.
@article{77fccf2ec2b5477b8bf977715933dd68,
title = "Heightened cytotoxic responses and impaired biogenesis contribute to early pathogenesis in the oral mucosa of simian immunodeficiency virus-infected rhesus macaques",
abstract = "Simian immunodeficiency virus (SIV) infection disseminated into the oropharyngeal tissues of rhesus macaques 6 weeks following intravenous inoculation. Severe local CD4 + T-cell depletion coincided with increases in NK cell and proinflammatory biomarkers and the disruption of growth-associated gene transcription, demonstrating the rapid establishment of pathogenesis in the oral mucosa.",
author = "George, {Michael D.} and David Verhoeven and Sumathi Sankaran-Walters and Tiffany Glavan and Elizabeth Reay and Satya Dandekar",
year = "2009",
month = "2",
doi = "10.1128/CVI.00265-08",
language = "English (US)",
volume = "16",
pages = "277--281",
journal = "Clinical and Vaccine Immunology",
issn = "1556-6811",
publisher = "American Society for Microbiology",
number = "2",

}

TY - JOUR

T1 - Heightened cytotoxic responses and impaired biogenesis contribute to early pathogenesis in the oral mucosa of simian immunodeficiency virus-infected rhesus macaques

AU - George, Michael D.

AU - Verhoeven, David

AU - Sankaran-Walters, Sumathi

AU - Glavan, Tiffany

AU - Reay, Elizabeth

AU - Dandekar, Satya

PY - 2009/2

Y1 - 2009/2

N2 - Simian immunodeficiency virus (SIV) infection disseminated into the oropharyngeal tissues of rhesus macaques 6 weeks following intravenous inoculation. Severe local CD4 + T-cell depletion coincided with increases in NK cell and proinflammatory biomarkers and the disruption of growth-associated gene transcription, demonstrating the rapid establishment of pathogenesis in the oral mucosa.

AB - Simian immunodeficiency virus (SIV) infection disseminated into the oropharyngeal tissues of rhesus macaques 6 weeks following intravenous inoculation. Severe local CD4 + T-cell depletion coincided with increases in NK cell and proinflammatory biomarkers and the disruption of growth-associated gene transcription, demonstrating the rapid establishment of pathogenesis in the oral mucosa.

UR - http://www.scopus.com/inward/record.url?scp=59649105749&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=59649105749&partnerID=8YFLogxK

U2 - 10.1128/CVI.00265-08

DO - 10.1128/CVI.00265-08

M3 - Article

C2 - 19091994

AN - SCOPUS:59649105749

VL - 16

SP - 277

EP - 281

JO - Clinical and Vaccine Immunology

JF - Clinical and Vaccine Immunology

SN - 1556-6811

IS - 2

ER -

Access to Document