Heightened cytotoxic responses and impaired biogenesis contribute to early pathogenesis in the oral mucosa of simian immunodeficiency virus-infected rhesus macaques

Michael D. George, David Verhoeven, Sumathi Sankaran-Walters, Tiffany Glavan, Elizabeth Reay, Satya Dandekar

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Simian immunodeficiency virus (SIV) infection disseminated into the oropharyngeal tissues of rhesus macaques 6 weeks following intravenous inoculation. Severe local CD4 + T-cell depletion coincided with increases in NK cell and proinflammatory biomarkers and the disruption of growth-associated gene transcription, demonstrating the rapid establishment of pathogenesis in the oral mucosa.

Original languageEnglish (US)
Pages (from-to)277-281
Number of pages5
JournalClinical and Vaccine Immunology
Volume16
Issue number2
DOIs
StatePublished - Feb 2009

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Immunology
  • Immunology and Allergy
  • Microbiology (medical)

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