Abstract
Simian immunodeficiency virus (SIV) infection disseminated into the oropharyngeal tissues of rhesus macaques 6 weeks following intravenous inoculation. Severe local CD4 + T-cell depletion coincided with increases in NK cell and proinflammatory biomarkers and the disruption of growth-associated gene transcription, demonstrating the rapid establishment of pathogenesis in the oral mucosa.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 277-281 |
| Number of pages | 5 |
| Journal | Clinical and Vaccine Immunology |
| Volume | 16 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2009 |
ASJC Scopus subject areas
- Clinical Biochemistry
- Immunology
- Immunology and Allergy
- Microbiology (medical)
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George, M. D., Verhoeven, D., Sankaran-Walters, S., Glavan, T., Reay, E., & Dandekar, S. (2009). Heightened cytotoxic responses and impaired biogenesis contribute to early pathogenesis in the oral mucosa of simian immunodeficiency virus-infected rhesus macaques. Clinical and Vaccine Immunology, 16(2), 277-281. https://doi.org/10.1128/CVI.00265-08