Heat shock proteins as markers of neural injury

Manuel F. Gonzalez, Kazuya Shiraishi, Kinya Hisanaga, Stephen M. Sagar, Mark Mandabach, Frank R Sharp

Research output: Contribution to journalArticle

278 Scopus citations

Abstract

Systemic or intracerebral injections of kainic acid induced immunoreactivity for the 72 kDa heat shock protein (HSP72) in individual neurons of the rat brain in patterns matching the known histopathology of the particular injury. HSP72 immunostaining was also induced in and around areas of infarction following experimental strokes. These results suggest that HSP72 immunocytochemistry may be used as a marker of cellular injury in the mammalian brain.

Original languageEnglish (US)
Pages (from-to)93-100
Number of pages8
JournalMolecular Brain Research
Volume6
Issue number1
DOIs
StatePublished - 1989
Externally publishedYes

Keywords

  • Brain ischemia
  • Heat shock protein
  • Kainic acid
  • Stroke

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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  • Cite this

    Gonzalez, M. F., Shiraishi, K., Hisanaga, K., Sagar, S. M., Mandabach, M., & Sharp, F. R. (1989). Heat shock proteins as markers of neural injury. Molecular Brain Research, 6(1), 93-100. https://doi.org/10.1016/0169-328X(89)90033-8