Heat shock protein hsp72 induction in cortical and striatal astrocytes and neurons following infarction

Frank R Sharp, Daniel Lowenstein, Roger Simon, Kinya Hisanaga

Research output: Contribution to journalArticle

118 Scopus citations

Abstract

Transient global and transient focal ischemia induced the 72 kDa heat shock protein (hsp72) in neurons in cortex, striatum, and other regions known to be injured during transient ischemia. A novel finding was the induction of hsp72 in islands (cylinders in three dimensions) of cells composed of astrocytes around the perimeter and neurons in the interior. Since histology showed pale staining in these regions, it is proposed that these islands rep-resent areas of focal infarction in the distribution of small cortical and lenticulostriate arteries. Although the factors responsible for hsp72 induction during ischemia and infarction are unknown, these results suggest differences in mechanisms of hsp72 induction in astrocytes compared to neurons.

Original languageEnglish (US)
Pages (from-to)621-627
Number of pages7
JournalJournal of Cerebral Blood Flow and Metabolism
Volume11
Issue number4
StatePublished - 1991
Externally publishedYes

Keywords

  • Astrocytes
  • Cerebral ischemia
  • Heat shock proteins
  • Neurons
  • Protein synthesis in ischemia
  • Stress proteins

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Neuroscience(all)

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