Heat shock protein hsp72 induction in cortical and striatal astrocytes and neurons following infarction

Frank R Sharp; Daniel Lowenstein; Roger Simon; Kinya Hisanaga

Heat shock protein hsp72 induction in cortical and striatal astrocytes and neurons following infarction

Frank R Sharp, Daniel Lowenstein, Roger Simon, Kinya Hisanaga

Research output: Contribution to journal › Article › peer-review

Abstract

Transient global and transient focal ischemia induced the 72 kDa heat shock protein (hsp72) in neurons in cortex, striatum, and other regions known to be injured during transient ischemia. A novel finding was the induction of hsp72 in islands (cylinders in three dimensions) of cells composed of astrocytes around the perimeter and neurons in the interior. Since histology showed pale staining in these regions, it is proposed that these islands rep-resent areas of focal infarction in the distribution of small cortical and lenticulostriate arteries. Although the factors responsible for hsp72 induction during ischemia and infarction are unknown, these results suggest differences in mechanisms of hsp72 induction in astrocytes compared to neurons.

Original language	English (US)
Pages (from-to)	621-627
Number of pages	7
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	11
Issue number	4
State	Published - 1991
Externally published	Yes

Keywords

Astrocytes
Cerebral ischemia
Heat shock proteins
Neurons
Protein synthesis in ischemia
Stress proteins

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism
Neuroscience(all)

Fingerprint Dive into the research topics of 'Heat shock protein hsp72 induction in cortical and striatal astrocytes and neurons following infarction'. Together they form a unique fingerprint.

Cite this

@article{ab2de1fd9be44441bdd401558c4a206c,

title = "Heat shock protein hsp72 induction in cortical and striatal astrocytes and neurons following infarction",

abstract = "Transient global and transient focal ischemia induced the 72 kDa heat shock protein (hsp72) in neurons in cortex, striatum, and other regions known to be injured during transient ischemia. A novel finding was the induction of hsp72 in islands (cylinders in three dimensions) of cells composed of astrocytes around the perimeter and neurons in the interior. Since histology showed pale staining in these regions, it is proposed that these islands rep-resent areas of focal infarction in the distribution of small cortical and lenticulostriate arteries. Although the factors responsible for hsp72 induction during ischemia and infarction are unknown, these results suggest differences in mechanisms of hsp72 induction in astrocytes compared to neurons.",

keywords = "Astrocytes, Cerebral ischemia, Heat shock proteins, Neurons, Protein synthesis in ischemia, Stress proteins",

author = "Sharp, {Frank R} and Daniel Lowenstein and Roger Simon and Kinya Hisanaga",

year = "1991",

language = "English (US)",

volume = "11",

pages = "621--627",

journal = "Journal of Cerebral Blood Flow and Metabolism",

issn = "0271-678X",

publisher = "Nature Publishing Group",

number = "4",

}

TY - JOUR

T1 - Heat shock protein hsp72 induction in cortical and striatal astrocytes and neurons following infarction

AU - Sharp, Frank R

AU - Lowenstein, Daniel

AU - Simon, Roger

AU - Hisanaga, Kinya

PY - 1991

Y1 - 1991

N2 - Transient global and transient focal ischemia induced the 72 kDa heat shock protein (hsp72) in neurons in cortex, striatum, and other regions known to be injured during transient ischemia. A novel finding was the induction of hsp72 in islands (cylinders in three dimensions) of cells composed of astrocytes around the perimeter and neurons in the interior. Since histology showed pale staining in these regions, it is proposed that these islands rep-resent areas of focal infarction in the distribution of small cortical and lenticulostriate arteries. Although the factors responsible for hsp72 induction during ischemia and infarction are unknown, these results suggest differences in mechanisms of hsp72 induction in astrocytes compared to neurons.

AB - Transient global and transient focal ischemia induced the 72 kDa heat shock protein (hsp72) in neurons in cortex, striatum, and other regions known to be injured during transient ischemia. A novel finding was the induction of hsp72 in islands (cylinders in three dimensions) of cells composed of astrocytes around the perimeter and neurons in the interior. Since histology showed pale staining in these regions, it is proposed that these islands rep-resent areas of focal infarction in the distribution of small cortical and lenticulostriate arteries. Although the factors responsible for hsp72 induction during ischemia and infarction are unknown, these results suggest differences in mechanisms of hsp72 induction in astrocytes compared to neurons.

KW - Astrocytes

KW - Cerebral ischemia

KW - Heat shock proteins

KW - Neurons

KW - Protein synthesis in ischemia

KW - Stress proteins

UR - http://www.scopus.com/inward/record.url?scp=0025785711&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025785711&partnerID=8YFLogxK

M3 - Article

C2 - 2050750

AN - SCOPUS:0025785711

VL - 11

SP - 621

EP - 627

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

SN - 0271-678X

IS - 4

ER -