Heart valve development: Endothelial cell signaling and differentiation

Ehrin J. Armstrong, Joyce Bischoff

Research output: Contribution to journalArticlepeer-review

497 Scopus citations


During the past decade, single gene disruption in mice and large-scale mutagenesis screens in zebrafish have elucidated many fundamental genetic pathways that govern early heart patterning and differentiation. Specifically, a number of genes have been revealed serendipitously to play important and selective roles in cardiac valve development. These initially surprising results have now converged on a finite number of signaling pathways that regulate endothelial proliferation and differentiation in developing and postnatal heart valves. This review highlights the roles of the most well-established ligands and signaling pathways, including VEGF, NFATc1, Notch, Wnt/β-catenin, BMP/TGF-β, ErbB, and NF1/Ras. Based on the interactions among and relative timing of these pathways, a signaling network model for heart valve development is proposed.

Original languageEnglish (US)
Pages (from-to)459-470
Number of pages12
JournalCirculation Research
Issue number5
StatePublished - Sep 3 2004
Externally publishedYes


  • Heart development
  • Heart valves
  • NFAT
  • TGF-β
  • Valvular heart disease
  • VEGF

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Heart valve development: Endothelial cell signaling and differentiation'. Together they form a unique fingerprint.

Cite this