Heart valve development: Endothelial cell signaling and differentiation

Ehrin J. Armstrong, Joyce Bischoff

Research output: Contribution to journalArticle

455 Citations (Scopus)

Abstract

During the past decade, single gene disruption in mice and large-scale mutagenesis screens in zebrafish have elucidated many fundamental genetic pathways that govern early heart patterning and differentiation. Specifically, a number of genes have been revealed serendipitously to play important and selective roles in cardiac valve development. These initially surprising results have now converged on a finite number of signaling pathways that regulate endothelial proliferation and differentiation in developing and postnatal heart valves. This review highlights the roles of the most well-established ligands and signaling pathways, including VEGF, NFATc1, Notch, Wnt/β-catenin, BMP/TGF-β, ErbB, and NF1/Ras. Based on the interactions among and relative timing of these pathways, a signaling network model for heart valve development is proposed.

Original languageEnglish (US)
Pages (from-to)459-470
Number of pages12
JournalCirculation Research
Volume95
Issue number5
DOIs
StatePublished - Sep 3 2004
Externally publishedYes

Fingerprint

Heart Valves
Cell Differentiation
Endothelial Cells
Catenins
Zebrafish
Mutagenesis
Vascular Endothelial Growth Factor A
Genes
Ligands

Keywords

  • Heart development
  • Heart valves
  • NFAT
  • TGF-β
  • Valvular heart disease
  • VEGF

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Heart valve development : Endothelial cell signaling and differentiation. / Armstrong, Ehrin J.; Bischoff, Joyce.

In: Circulation Research, Vol. 95, No. 5, 03.09.2004, p. 459-470.

Research output: Contribution to journalArticle

Armstrong, Ehrin J. ; Bischoff, Joyce. / Heart valve development : Endothelial cell signaling and differentiation. In: Circulation Research. 2004 ; Vol. 95, No. 5. pp. 459-470.
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