Heart failure and chronic kidney disease in a registry of internal medicine wards

Pier Mannuccio Mannucci, Alessandro Nobili, Mauro Tettamanti, Luca Pasina, Carlotta Franchi, Francesco Salerno, Salvatore Corrao, Alessandra Marengoni, Alfonso Iorio, Maura Marcucci, Eleonora Sparacio, Stefania Alborghetti, Rosa Di Costanzo, Codjo Djignefa Djade, Domenico Prisco, Elena Silvestri, Caterina Cenci, Tommaso Barnini, Giuseppe Delitala, Stefano CartaSebastiana Atzori, Gianfranco Guarnieri, Michela Zanetti, Annalisa Spalluti, Maria Grazia Serra, Maria Antonietta Bleve, Massimo Vanoli, Giulia Grignani, Gianluca Casella, Laura Gasbarrone, Giorgio Maniscalco, Massimo Gunelli, Daniela Tirotta, Antonio Brucato, Silvia Ghidoni, Paola Di Corato, Mauro Bernardi, Silvia Li Bassi, Luca Santi, Giancarlo Agnelli, Emanuela Marchesini, Elmo Mannarino, Graziana Lupattelli, Pamela Rondelli, Francesco Paciullo, Fabrizio Fabris, Michela Carlon, Francesca Turatto, Maria Cristina Baroni, Marianna Zardo, Roberto Manfredini, Christian Molino, Marco Pala, Fabio Fabbian, Ranuccio Nuti, Roberto Valenti, Martina Ruvio, Silvia Cappelli, Giuseppe Paolisso, Maria Rosaria Rizzo, Maria Teresa Laieta, Teresa Salvatore, Ferdinando Carlo Sasso, Riccardo Utili, Emanuele Durante Mangoni, Daniela Pinto, Oliviero Olivieri, Anna Maria Stanzial, Renato Fellin, Stefano Volpato, Sioulis Fotini, Mario Barbagallo, Ligia Dominguez, Lidia Plances, Daniela D'Angelo, Giovanbattista Rini, Pasquale Mansueto, Ilenia Pepe, Giuseppe Licata, Luigi Calvo, Maria Valenti, Claudio Borghi, Enrico Strocchi, Elisa Rebecca Rinaldi, Marco Zoli, Elisa Fabbri, Donatella Magalotti, Alberto Auteri, Anna Laura Pasqui, Luca Puccetti, Franco Laghi Pasini, Pier Leopoldo Capecchi, Maurizio Bicchi, Carlo Sabbà, Francesco Saverio Vella, Alessandro Marseglia, Chiara Valentina Luglio, Giuseppe Palasciano, Maria Ester Modeo, Annamaria Aquilino, Pallante Raffaele, Stefania Pugliese, Caterina Capobianco, Alfredo Postiglione, Maria Rosaria Barbella, Francesco De Stefano, Luigi Fenoglio, Chiara Brignone, Christian Bracco, Alessia Giraudo, Giuseppe Musca, Olga Cuccurullo, Luigi Cricco, Alessandra Fiorentini, Maria Domenica Cappellini, Giovanna Fabio, Sonia Seghezzi, Margherita Migone De Amicis, Silvia Fargion, Paola Bonara, Mara Bulgheroni, Rosa Lombardi, Fabio Magrini, Ferdinando Massari, Tatiana Tonella, Flora Peyvandi, Alberto Tedeschi, Raffaella Rossio, Guido Moreo, Barbara Ferrari, Luisa Roncari, Valter Monzani, Valeria Savojardo, Christian Folli, Maria Magnini, Daniela Mari, Paolo Dionigi Rossi, Sarah Damanti, Silvia Prolo, Maria Sole Lilleri, Giuliana Micale, Mauro Podda, Carlo Selmi, Francesca Meda, Silvia Accordino, Alessio Conca, Valentina Monti, Gino Roberto Corazza, Emanuela Miceli, Marco Vincenzo Lenti, Donatella Padula, Carlo L. Balduini, Giampiera Bertolino, Stella Provini, Federica Quaglia, Giovanni Murialdo, Marta Bovio, Franco Dallegri, Luciano Ottonello, Alessandra Quercioli, Alessandra Barreca, Maria Beatrice Secchi, Davide Ghelfi, Wu Sheng Chin, Laura Carassale, Silvia Caporotundo, Luigi Anastasio, Lucia Sofia, Maria Carbone, Giancarlo Traisci, Lucrezia De Feudis, Silvia Di Carlo, Giovanni Davì, Maria Teresa Guagnano, Simona Sestili, Elisabetta Bergami, Emanuela Rizzioli, Carlo Cagnoni, Luca Bertone, Antonio Manucra, Alberto Buratti, Tiziana Tognin, Nicola Lucio Liberato, Giordano Bernasconi, Barbara Nardo, Giovanni Battista Bianchi, Sabrina Giaquinto Ospedale, Giampiero Benetti, Michela Quagliolo, Giuseppe Riccardo Centenaro, Francesco Purrello, Antonino Di Pino, Salvatore Piro, Gerardo Mancuso, Daniela Calipari, Mosè Bartone, Francesco Gullo, Michele Cortellaro, Marina Magenta, Francesca Perego, Maria Rachele Meroni, Marco Cicardi, Antonio Gidaro Marina Magenta, Andrea Sacco, Antonio Bonelli, Gaetano Dentamaro, Renzo Rozzini, Lina Falanga, Alessandro Giordano, Paolo Cavallo Perin, Bartolomeo Lorenzati, Gabriella Gruden, Graziella Bruno, Giuseppe Montrucchio, Elisabetta Greco, Pietro Tizzani, Giacomo Fera, Maria Loreta Di Luca, Donatella Renna, Antonio Perciccante, Alessia Coralli, Rodolfo Tassara, Deborah Melis, Lara Rebella, Giorgio Menardo, Stefania Bottone, Elsa Sferrazzo, Claudio Ferri, Rinaldo Striuli, Rosa Scipioni, Raffaella Salmi, Piergiorgio Gaudenzi, Susanna Gamberini, Franco Ricci, Cosimo Morabito, Roberto Fava, Andrea Semplicini, Lucia Gottardo, Gianluigi Vendemiale, Gaetano Serviddio, Roberta Forlano, Luigi Bolondi, Leonardo Rasciti, Ilaria Serio, Cesare Masala, Antonio Mammarella, Valeria Raparelli, Filippo Rossi Fanelli, Massimo Delfino, Antonio Amoroso, Francesco Violi, Stefania Basili, Ludovica Perri, Pietro Serra, Vincenzo Fontana, Marco Falcone, Raffaele Landolfi, Antonio Grieco, Antonella Gallo, Giuseppe Zuccalà, Francesco Franceschi, Guido De Marco, Cordischi Chiara, Sabbatini Marta, Martino Bellusci, Donatella Setti, Filippo Pedrazzoli, Giuseppe Romanelli, Caterina Pirali, Claudia Amolini, Enrico Agabiti Rosei, Damiano Rizzoni, Luana Castoldi, Antonio Picardi, Umberto Vespasiani Gentilucci, Chiara Mazzarelli, Paolo Gallo, Luigina Guasti, Luana Castiglioni, Andrea Maresca, Alessandro Squizzato, Sara Contini, Marta Molaro, Giorgio Annoni, Maurizio Corsi, Sara Zazzetta, Marco Bertolotti, Chiara Mussi, Roberto Scotto, Maria Alice Ferri, Francesca Veltri, Franco Arturi, Elena Succurro, Giorgio Sesti, Umberto Gualtieri, Francesco Perticone, Angela Sciacqua, Michele Quero, Chiara Bagnato, Paola Loria, Maria Angela Becchi, Gianfranco Martucci, Alessandra Fantuzzi, Mauro Maurantonio, Roberto Corinaldesi, Roberto De Giorgio, Mauro Serra, Valentina Grasso, Eugenio Ruggeri, Lorenzo Mauro Carozza, Fabio Pignatti, G. Lupattelli, G. Reboldi, F. Paciullo, G. Vaudo, M. Pirro, L. Pasqualini, A. Nobili, P. M. Mannucci, E. Mannarino

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Background: The aim of the present study was to evaluate the association between heart failure (HF) and chronic kidney disease (CKD) in tertiary care centers using the clinical records of patients enrolled in internal medicine departments.

Patients and methods: We used the clinical records of 1380 elderly patients to identify patients with a history of HF and CKD using admission ICD codes and glomerular filtration rate (GFR) formulas. Magnitude and strength of such associations were investigated by univariable and multivariable analysis.

Results: Of the 1380 patients enrolled, 27.9% had HF (age 80 ± 7, BMI 27 ± 6 kg/m2) and 17.4% CKD (age 81 ± 7, BMI 26.8 ± 6 kg/m2). Both groups were significantly older (P <' 0.0001) with BMI higher than the patients without those diagnosis (P < 0.02). Patients with a history of CKD showed higher non-fasting glycaemia (140 ± 86 vs. 125 ± 63 mg/dL, P < 0.001). CKD was significantly associated with HF (P < 0.0001). Patients with HF had an estimated GFR lower than patients without HF (P < 0.0001). Comorbidity and severity indices were significantly higher in subjects with HF (P < 0.0001) and CKD (P < 0.0001) than in those without. Multivariable analysis showed a significant association between HF and age (for five years increase OR 1.13, P < 0.009), BMI (for each 3 kg/m2 increase OR 1.15, P < 0.001), GFR (for each decrease of 10 mL/min increase OR 0.92, P < 0.002) and severity index (IS) (for each 0.25 units increase OR 1.43, P < 0.001).

Conclusion: HF on admission is strongly associated with CKD, older age, BMI, and SI. These data focus the value of epidemiological studies such REPOSI in identifying and monitoring multimorbidity in elderly.

Original languageEnglish (US)
Pages (from-to)307-313
Number of pages7
JournalEuropean Geriatric Medicine
Volume5
Issue number5
DOIs
StatePublished - Oct 1 2014
Externally publishedYes

Keywords

  • Chronic kidney disease
  • Elderly
  • Heart failure
  • REPOSI

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Gerontology

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  • Cite this

    Mannucci, P. M., Nobili, A., Tettamanti, M., Pasina, L., Franchi, C., Salerno, F., Corrao, S., Marengoni, A., Iorio, A., Marcucci, M., Sparacio, E., Alborghetti, S., Di Costanzo, R., Djade, C. D., Prisco, D., Silvestri, E., Cenci, C., Barnini, T., Delitala, G., ... Mannarino, E. (2014). Heart failure and chronic kidney disease in a registry of internal medicine wards. European Geriatric Medicine, 5(5), 307-313. https://doi.org/10.1016/j.rppneu.2014.03.009