Health effects of indoor air pollution: Synergistic effects of nitrogen dioxide and a respirable aerosol

Research output: Contribution to journalArticle

Abstract

Comparative studies of the effects of various air pollutants on lung collagen biosynthesis have been performed. A hitherto unexpected synergism between the oxidant air pollutants ozone or nitrogen dioxide and a respirable-sized aerosol of ammonium sulfate was observed during controlled exposures of rats to these substances. In an assay system, measuring collagen biosynthesis by lung minces prepared from rats exposed for 1 week to either filtered air or to these pollutants gases, dose-response curves to either O3 or NO2 are altered in the presence of 5 mg/m3 of (NH4)2SO4 aerosol. These observations may have broad implications for the appropriate evaluation of laboratory data in the setting of ambient air quality standards and/or the setting of threshold limit values for maintenance of occupational health and safety.

Original languageEnglish (US)
Pages (from-to)319-322
Number of pages4
JournalEnvironment International
Volume9
Issue number4
DOIs
StatePublished - 1983

Fingerprint

Indoor air pollution
Nitrogen Dioxide
Air Pollutants
collagen
Biosynthesis
nitrogen dioxide
Aerosols
Rats
Collagen
Health
aerosol
Air quality standards
synergism
Ozone
Ammonium Sulfate
ammonium sulfate
health and safety
Oxidants
oxidant
ambient air

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry

Cite this

@article{77b0a96f7fef42858c83e4a2c3be1954,
title = "Health effects of indoor air pollution: Synergistic effects of nitrogen dioxide and a respirable aerosol",
abstract = "Comparative studies of the effects of various air pollutants on lung collagen biosynthesis have been performed. A hitherto unexpected synergism between the oxidant air pollutants ozone or nitrogen dioxide and a respirable-sized aerosol of ammonium sulfate was observed during controlled exposures of rats to these substances. In an assay system, measuring collagen biosynthesis by lung minces prepared from rats exposed for 1 week to either filtered air or to these pollutants gases, dose-response curves to either O3 or NO2 are altered in the presence of 5 mg/m3 of (NH4)2SO4 aerosol. These observations may have broad implications for the appropriate evaluation of laboratory data in the setting of ambient air quality standards and/or the setting of threshold limit values for maintenance of occupational health and safety.",
author = "Last, {Jerold A}",
year = "1983",
doi = "10.1016/0160-4120(83)90092-2",
language = "English (US)",
volume = "9",
pages = "319--322",
journal = "Environmental International",
issn = "0160-4120",
publisher = "Elsevier Limited",
number = "4",

}

TY - JOUR

T1 - Health effects of indoor air pollution

T2 - Synergistic effects of nitrogen dioxide and a respirable aerosol

AU - Last, Jerold A

PY - 1983

Y1 - 1983

N2 - Comparative studies of the effects of various air pollutants on lung collagen biosynthesis have been performed. A hitherto unexpected synergism between the oxidant air pollutants ozone or nitrogen dioxide and a respirable-sized aerosol of ammonium sulfate was observed during controlled exposures of rats to these substances. In an assay system, measuring collagen biosynthesis by lung minces prepared from rats exposed for 1 week to either filtered air or to these pollutants gases, dose-response curves to either O3 or NO2 are altered in the presence of 5 mg/m3 of (NH4)2SO4 aerosol. These observations may have broad implications for the appropriate evaluation of laboratory data in the setting of ambient air quality standards and/or the setting of threshold limit values for maintenance of occupational health and safety.

AB - Comparative studies of the effects of various air pollutants on lung collagen biosynthesis have been performed. A hitherto unexpected synergism between the oxidant air pollutants ozone or nitrogen dioxide and a respirable-sized aerosol of ammonium sulfate was observed during controlled exposures of rats to these substances. In an assay system, measuring collagen biosynthesis by lung minces prepared from rats exposed for 1 week to either filtered air or to these pollutants gases, dose-response curves to either O3 or NO2 are altered in the presence of 5 mg/m3 of (NH4)2SO4 aerosol. These observations may have broad implications for the appropriate evaluation of laboratory data in the setting of ambient air quality standards and/or the setting of threshold limit values for maintenance of occupational health and safety.

UR - http://www.scopus.com/inward/record.url?scp=0021063871&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021063871&partnerID=8YFLogxK

U2 - 10.1016/0160-4120(83)90092-2

DO - 10.1016/0160-4120(83)90092-2

M3 - Article

AN - SCOPUS:0021063871

VL - 9

SP - 319

EP - 322

JO - Environmental International

JF - Environmental International

SN - 0160-4120

IS - 4

ER -