Health effects of indoor air pollution: Synergistic effects of nitrogen dioxide and a respirable aerosol

Research output: Contribution to journalArticle

Abstract

Comparative studies of the effects of various air pollutants on lung collagen biosynthesis have been performed. A hitherto unexpected synergism between the oxidant air pollutants ozone or nitrogen dioxide and a respirable-sized aerosol of ammonium sulfate was observed during controlled exposures of rats to these substances. In an assay system, measuring collagen biosynthesis by lung minces prepared from rats exposed for 1 week to either filtered air or to these pollutants gases, dose-response curves to either O3 or NO2 are altered in the presence of 5 mg/m3 of (NH4)2SO4 aerosol. These observations may have broad implications for the appropriate evaluation of laboratory data in the setting of ambient air quality standards and/or the setting of threshold limit values for maintenance of occupational health and safety.

Original languageEnglish (US)
Pages (from-to)319-322
Number of pages4
JournalEnvironment International
Volume9
Issue number4
DOIs
StatePublished - 1983

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry

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