Health concerns and management of select veterinary drug residues

Ronald E. Baynes, Keith Dedonder, Lindsey Kissell, Danielle Mzyk, Tara Marmulak, Geof Smith, Lisa A Tell, Ronette Gehring, Jennifer Davis, Jim E. Riviere

Research output: Contribution to journalReview article

56 Citations (Scopus)

Abstract

The aim of this manuscript is to review the potential adverse health effects in humans if exposed to residues of selected veterinary drugs used in food-producing animals. Our other objectives are to briefly inform the reader of why many of these drugs are or were approved for use in livestock production and how drug residues can be mitigated for these drugs. The selected drugs include several antimicrobials, beta agonists, and phenylbutazone. The antimicrobials continue to be of regulatory concern not only because of their acute adverse effects but also because their use as growth promoters have been linked to antimicrobial resistance. Furthermore, nitroimidazoles and arsenicals are no longer approved for use in food animals in most jurisdictions. In recent years, the risk assessment and risk management of beta agonists, have been the focus of national and international agencies and this manuscript attempts to review the pharmacology of these drugs and regulatory challenges. Several of the drugs selected for this review can cause noncancer effects (e.g., penicillins) and others are potential carcinogens (e.g., nitroimidazoles). This review also focuses on how regulatory and independent organizations manage the risk of these veterinary drugs based on data from human health risk assessments.

Original languageEnglish (US)
Pages (from-to)112-122
Number of pages11
JournalFood and Chemical Toxicology
Volume88
DOIs
StatePublished - Feb 1 2016

Fingerprint

Drug Residues
Veterinary Drugs
drug residues
veterinary drugs
Health
drugs
nitroimidazoles
Nitroimidazoles
beta-adrenergic agonists
Pharmaceutical Preparations
Risk assessment
risk assessment
Animals
anti-infective agents
adverse effects
arsenicals
Arsenicals
International Agencies
phenylbutazone
Phenylbutazone

Keywords

  • Adverse
  • Drug
  • Livestock
  • Residue
  • Veterinary

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Baynes, R. E., Dedonder, K., Kissell, L., Mzyk, D., Marmulak, T., Smith, G., ... Riviere, J. E. (2016). Health concerns and management of select veterinary drug residues. Food and Chemical Toxicology, 88, 112-122. https://doi.org/10.1016/j.fct.2015.12.020

Health concerns and management of select veterinary drug residues. / Baynes, Ronald E.; Dedonder, Keith; Kissell, Lindsey; Mzyk, Danielle; Marmulak, Tara; Smith, Geof; Tell, Lisa A; Gehring, Ronette; Davis, Jennifer; Riviere, Jim E.

In: Food and Chemical Toxicology, Vol. 88, 01.02.2016, p. 112-122.

Research output: Contribution to journalReview article

Baynes, RE, Dedonder, K, Kissell, L, Mzyk, D, Marmulak, T, Smith, G, Tell, LA, Gehring, R, Davis, J & Riviere, JE 2016, 'Health concerns and management of select veterinary drug residues', Food and Chemical Toxicology, vol. 88, pp. 112-122. https://doi.org/10.1016/j.fct.2015.12.020
Baynes RE, Dedonder K, Kissell L, Mzyk D, Marmulak T, Smith G et al. Health concerns and management of select veterinary drug residues. Food and Chemical Toxicology. 2016 Feb 1;88:112-122. https://doi.org/10.1016/j.fct.2015.12.020
Baynes, Ronald E. ; Dedonder, Keith ; Kissell, Lindsey ; Mzyk, Danielle ; Marmulak, Tara ; Smith, Geof ; Tell, Lisa A ; Gehring, Ronette ; Davis, Jennifer ; Riviere, Jim E. / Health concerns and management of select veterinary drug residues. In: Food and Chemical Toxicology. 2016 ; Vol. 88. pp. 112-122.
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