HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research

for HD physiology project investigators

Research output: Contribution to journalReview article

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Abstract

The HD Physiology Project is a Japanese research consortium that aimed to develop methods and a computational platform in which physiological and pathological information can be described in high-level definitions across multiple scales of time and size. During the 5 years of this project, an appropriate software platform for multilevel functional simulation was developed and a whole-heart model including pharmacokinetics for the assessment of the proarrhythmic risk of drugs was developed. In this article, we outline the description and scientific strategy of this project and present the achievements and influence on multilevel integrative systems biology and physiome research.

Original languageEnglish (US)
Article number1
Journalnpj Systems Biology and Applications
Volume3
Issue number1
DOIs
StatePublished - Dec 1 2017
Externally publishedYes

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ASJC Scopus subject areas

  • Computer Science Applications
  • Applied Mathematics
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Drug Discovery

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