HATs on and beyond chromatin

Hongwu Chen, Marc Tini, Ronald M. Evans

Research output: Contribution to journalArticlepeer-review

144 Scopus citations

Abstract

The role of histone acetylation as a key mechanism of transcriptional regulation has been well established. Recent advances suggest that histone acetyltransferases also play important roles in histone-modulated processes such as DNA replication, recombination and repair. In addition, acetylation of transcriptional cofactors and other proteins is an efficient means of regulating a diverse range of molecular interactions. As new histone acetyltransferases and substrates are rapidly emerging, it is becoming apparent that protein acetylation may rival phosphorylation as a mechanism to transduce cellular regulatory signals.

Original languageEnglish (US)
Pages (from-to)218-224
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume13
Issue number2
DOIs
StatePublished - Apr 1 2001

ASJC Scopus subject areas

  • Cell Biology

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