Has electrical growth cone guidance found its potential?

Colin D. McCaig, Ann M. Rajnicek, Bing Song, Min Zhao

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Many neurobiologists spurn the existence and use of direct-current (DC) electric fields (EFs) in nervous system development and regeneration. This is despite direct measurement of EFs in embryos and adults, and evidence that EFs are required for normal development, dramatically influence the rate and direction of nerve growth in vitro, and promote nerve regeneration in vivo. The notion that growth cones use EFs as guidance cues was dismissed partly because there was no convincing evidence that naturally occurring EFs influence nerve growth at the single-cell level in vivo. Recent work indicates that growth cones can be guided by EFs in vivo and, intriguingly, that in vitro guidance by chemotropic gradients and EFs might invoke similar mechanisms. Ongoing clinical trials to assess the effectiveness of DC EFs in promoting the regeneration of human spinal cord could allow EFs to achieve their potential.

Original languageEnglish (US)
Pages (from-to)354-359
Number of pages6
JournalTrends in Neurosciences
Volume25
Issue number7
DOIs
StatePublished - Jul 1 2002
Externally publishedYes

Fingerprint

Growth Cones
Spinal Cord Regeneration
Nerve Regeneration
Growth
Nervous System
Cues
Regeneration
Embryonic Structures
Clinical Trials
In Vitro Techniques
Direction compound

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Has electrical growth cone guidance found its potential? / McCaig, Colin D.; Rajnicek, Ann M.; Song, Bing; Zhao, Min.

In: Trends in Neurosciences, Vol. 25, No. 7, 01.07.2002, p. 354-359.

Research output: Contribution to journalArticle

McCaig, Colin D. ; Rajnicek, Ann M. ; Song, Bing ; Zhao, Min. / Has electrical growth cone guidance found its potential?. In: Trends in Neurosciences. 2002 ; Vol. 25, No. 7. pp. 354-359.
@article{1e9d0f44853d4ee489b793a218805caf,
title = "Has electrical growth cone guidance found its potential?",
abstract = "Many neurobiologists spurn the existence and use of direct-current (DC) electric fields (EFs) in nervous system development and regeneration. This is despite direct measurement of EFs in embryos and adults, and evidence that EFs are required for normal development, dramatically influence the rate and direction of nerve growth in vitro, and promote nerve regeneration in vivo. The notion that growth cones use EFs as guidance cues was dismissed partly because there was no convincing evidence that naturally occurring EFs influence nerve growth at the single-cell level in vivo. Recent work indicates that growth cones can be guided by EFs in vivo and, intriguingly, that in vitro guidance by chemotropic gradients and EFs might invoke similar mechanisms. Ongoing clinical trials to assess the effectiveness of DC EFs in promoting the regeneration of human spinal cord could allow EFs to achieve their potential.",
author = "McCaig, {Colin D.} and Rajnicek, {Ann M.} and Bing Song and Min Zhao",
year = "2002",
month = "7",
day = "1",
doi = "10.1016/S0166-2236(02)02174-4",
language = "English (US)",
volume = "25",
pages = "354--359",
journal = "Trends in Neurosciences",
issn = "0378-5912",
publisher = "Elsevier Limited",
number = "7",

}

TY - JOUR

T1 - Has electrical growth cone guidance found its potential?

AU - McCaig, Colin D.

AU - Rajnicek, Ann M.

AU - Song, Bing

AU - Zhao, Min

PY - 2002/7/1

Y1 - 2002/7/1

N2 - Many neurobiologists spurn the existence and use of direct-current (DC) electric fields (EFs) in nervous system development and regeneration. This is despite direct measurement of EFs in embryos and adults, and evidence that EFs are required for normal development, dramatically influence the rate and direction of nerve growth in vitro, and promote nerve regeneration in vivo. The notion that growth cones use EFs as guidance cues was dismissed partly because there was no convincing evidence that naturally occurring EFs influence nerve growth at the single-cell level in vivo. Recent work indicates that growth cones can be guided by EFs in vivo and, intriguingly, that in vitro guidance by chemotropic gradients and EFs might invoke similar mechanisms. Ongoing clinical trials to assess the effectiveness of DC EFs in promoting the regeneration of human spinal cord could allow EFs to achieve their potential.

AB - Many neurobiologists spurn the existence and use of direct-current (DC) electric fields (EFs) in nervous system development and regeneration. This is despite direct measurement of EFs in embryos and adults, and evidence that EFs are required for normal development, dramatically influence the rate and direction of nerve growth in vitro, and promote nerve regeneration in vivo. The notion that growth cones use EFs as guidance cues was dismissed partly because there was no convincing evidence that naturally occurring EFs influence nerve growth at the single-cell level in vivo. Recent work indicates that growth cones can be guided by EFs in vivo and, intriguingly, that in vitro guidance by chemotropic gradients and EFs might invoke similar mechanisms. Ongoing clinical trials to assess the effectiveness of DC EFs in promoting the regeneration of human spinal cord could allow EFs to achieve their potential.

UR - http://www.scopus.com/inward/record.url?scp=0036641820&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036641820&partnerID=8YFLogxK

U2 - 10.1016/S0166-2236(02)02174-4

DO - 10.1016/S0166-2236(02)02174-4

M3 - Article

VL - 25

SP - 354

EP - 359

JO - Trends in Neurosciences

JF - Trends in Neurosciences

SN - 0378-5912

IS - 7

ER -