Harnessing neural stem cells for treating psychiatric symptoms associated with fetal alcohol spectrum disorder and epilepsy

Trenton Lippert, Lindsey Gelineau, Eleonora Napoli, Cesar V. Borlongan

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Brain insults with progressive neurodegeneration are inherent in pathological symptoms that represent many psychiatric illnesses. Neural network disruptions characterized by impaired neurogenesis have been recognized to precede, accompany, and possibly even exacerbate the evolution and progression of symptoms of psychiatric disorders. Here, we focus on the neurodegeneration and the resulting psychiatric symptoms observed in fetal alcohol spectrum disorder and epilepsy, in an effort to show that these two diseases are candidate targets for stem cell therapy. In particular, we provide preclinical evidence in the transplantation of neural stem cells (NSCs) in both conditions, highlighting the potential of this cell-based treatment for correcting the psychiatric symptoms that plague these two disorders. Additionally, we discuss the challenges of NSC transplantation and offer insights into the mechanisms that may mediate the therapeutic benefits and can be exploited to overcome the hurdles of translating this therapy from the laboratory to the clinic. Our ultimate goal is to advance stem cell therapy for the treatment of psychiatric disorders.

Original languageEnglish (US)
Pages (from-to)10-22
Number of pages13
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume80
DOIs
StatePublished - Jan 3 2018

Fingerprint

Fetal Alcohol Spectrum Disorders
Neural Stem Cells
Psychiatry
Epilepsy
Cell- and Tissue-Based Therapy
Stem Cells
Plague
Neurogenesis
Stem Cell Transplantation
Therapeutics
Transplantation
Brain

Keywords

  • Alcohol
  • Epilepsy
  • Fetal alcohol spectrum disorder
  • GABA
  • Neural stem cells
  • Neurodegeneration
  • Teratogenecity
  • Transplantation

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

Cite this

Harnessing neural stem cells for treating psychiatric symptoms associated with fetal alcohol spectrum disorder and epilepsy. / Lippert, Trenton; Gelineau, Lindsey; Napoli, Eleonora; Borlongan, Cesar V.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 80, 03.01.2018, p. 10-22.

Research output: Contribution to journalReview article

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