Haplotype structure of the mouse genome

Jianmei Wang, Guochun Liao, Janet Cheng, Anh Nguyen, Jingshu Guo, Christopher Chou, Steven Hu, Sharon Jiang, John Allard, Steve Shafer, Anne Puech, John Douglas Mcpherson, Dorothee Foernzler, Gary Peltz, Jonathan Usuka

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Scopus citations

Abstract

Commonly available inbred mouse strains can be used to genetically model traits that vary in the human population, including those associated with disease susceptibility. In order to understand how genetic differences regulate trait variation in humans, we must first develop a detailed understanding of how genetic variation in the mouse produces the phenotypic differences among inbred mouse strains. The information obtained from analysis of experimental murine genetic models can direct biological experimentation, clinical research, and human genetic analysis. This mouse to man approach will increase our knowledge of the genes and pathways regulating important biological processes and disease susceptibility.

Original languageEnglish (US)
Title of host publicationComputational Genetics and Genomics: Tools for Understanding Disease
PublisherHumana Press Inc.
Pages71-83
Number of pages13
ISBN (Electronic)9781592599301
ISBN (Print)1592599303, 9781588291875
DOIs
StatePublished - 2005
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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