Abstract
We examined the effects of chronic (2 weeks) treatment with a typical neuroleptic, haloperidol (1 mg/kg, s.c.), and an atypical neuroleptic, clozapine (20 mg/kg, s.c.), on neurotensin receptor (NTR) mRNA levels by in situ hybridization histochemistry. Quantitative OD analysis showed haloperidol-induced NTR mRNA levels in the substantia nigra/ventral tegmental area (SN/ VTA) 110% over control levels (significant difference from the control, p < 0.05). In contrast, the same analysis applied to the sections from clozapine-treated animals showed no significant change in NTR mRNA levels compared with matched control sections (p > 0.05). Thus, chronic treatment with haloperidol but not clozapine resulted in elevated levels of NTR mRNA within the SN/VTA. These results suggest that the high incidence of extrapyramidal side effects of typical neuroleptics could result from changes in NTR expression in the SN/VTA.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1141-1143 |
| Number of pages | 3 |
| Journal | Journal of Neurochemistry |
| Volume | 61 |
| Issue number | 3 |
| State | Published - Sep 1993 |
| Externally published | Yes |
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Keywords
- Atypical neuroleptics
- Extrapyramidal side effects
- In situ hybridization histochemistry
ASJC Scopus subject areas
- Biochemistry
- Cellular and Molecular Neuroscience
Cite this
Haloperidol but not clozapine increases neurotensin receptor mRNA levels in rat substantia nigra. / Bolden-Watson, Carolyn; Watson, Michael A.; Murray, Karl D; Isackson, Paul J.; Richelson, Elliott.
In: Journal of Neurochemistry, Vol. 61, No. 3, 09.1993, p. 1141-1143.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Haloperidol but not clozapine increases neurotensin receptor mRNA levels in rat substantia nigra
AU - Bolden-Watson, Carolyn
AU - Watson, Michael A.
AU - Murray, Karl D
AU - Isackson, Paul J.
AU - Richelson, Elliott
PY - 1993/9
Y1 - 1993/9
N2 - We examined the effects of chronic (2 weeks) treatment with a typical neuroleptic, haloperidol (1 mg/kg, s.c.), and an atypical neuroleptic, clozapine (20 mg/kg, s.c.), on neurotensin receptor (NTR) mRNA levels by in situ hybridization histochemistry. Quantitative OD analysis showed haloperidol-induced NTR mRNA levels in the substantia nigra/ventral tegmental area (SN/ VTA) 110% over control levels (significant difference from the control, p < 0.05). In contrast, the same analysis applied to the sections from clozapine-treated animals showed no significant change in NTR mRNA levels compared with matched control sections (p > 0.05). Thus, chronic treatment with haloperidol but not clozapine resulted in elevated levels of NTR mRNA within the SN/VTA. These results suggest that the high incidence of extrapyramidal side effects of typical neuroleptics could result from changes in NTR expression in the SN/VTA.
AB - We examined the effects of chronic (2 weeks) treatment with a typical neuroleptic, haloperidol (1 mg/kg, s.c.), and an atypical neuroleptic, clozapine (20 mg/kg, s.c.), on neurotensin receptor (NTR) mRNA levels by in situ hybridization histochemistry. Quantitative OD analysis showed haloperidol-induced NTR mRNA levels in the substantia nigra/ventral tegmental area (SN/ VTA) 110% over control levels (significant difference from the control, p < 0.05). In contrast, the same analysis applied to the sections from clozapine-treated animals showed no significant change in NTR mRNA levels compared with matched control sections (p > 0.05). Thus, chronic treatment with haloperidol but not clozapine resulted in elevated levels of NTR mRNA within the SN/VTA. These results suggest that the high incidence of extrapyramidal side effects of typical neuroleptics could result from changes in NTR expression in the SN/VTA.
KW - Atypical neuroleptics
KW - Extrapyramidal side effects
KW - In situ hybridization histochemistry
UR - http://www.scopus.com/inward/record.url?scp=0027261520&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027261520&partnerID=8YFLogxK
M3 - Article
VL - 61
SP - 1141
EP - 1143
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
SN - 0022-3042
IS - 3
ER -