Hallucinations, delusions, and cognitive decline in Alzheimer's disease

Robert S. Wilson, David W. Gilley, David A. Bennett, Laurel A Beckett, Denis A. Evans

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Objectives - To examine the occurrence of hallucinations and delusions in Alzheimer's disease over a 4 year period and their association with rate of cognitive decline. Methods - A cohort of 410 persons with clinically diagnosed Alzheimer's disease underwent annual clinical evaluations over a 4 year period. Participation in follow up exceeded 90% in survivors. Evaluations included structured informant interview, from which the presence or absence of hallucinations and delusions was ascertained, and detailed testing of cognitive function. The primary cognitive outcome measure was a composite cognitive score based on 17 individual performance tests. The mini mental state examination (MMSE) and summary measures of memory, visuoconstruction, repetition, and naming were used in secondary analyses. Results - At baseline, hallucinations (present in 41%) and delusions (present in 55%) were common and associated with lower cognitive function. In analyses that controlled for baseline level of cognitive function, demographic variables, parkinsonism, and use of antipsychotic medications, hallucinations, but not delusions, were associated with more rapid cognitive decline on each cognitive measure. In the primary model, there was a 47% increase in the average annual rate of decline on a composite cognitive measure in those with baseline hallucinations compared with those without them. This effect was mainly due to a subgroup with both auditory and visual hallucinations. Conclusion - These findings suggest that the presence of hallucinations is selectively associated with more rapid cognitive decline in Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)172-177
Number of pages6
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume69
Issue number2
DOIs
StatePublished - Aug 2000
Externally publishedYes

Fingerprint

Delusions
Hallucinations
Alzheimer Disease
Cognition
Cognitive Dysfunction
Parkinsonian Disorders
Antipsychotic Agents
Survivors
Demography
Outcome Assessment (Health Care)
Interviews

Keywords

  • Alzheimer's disease
  • Cognitive decline
  • Hallucinations

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

Hallucinations, delusions, and cognitive decline in Alzheimer's disease. / Wilson, Robert S.; Gilley, David W.; Bennett, David A.; Beckett, Laurel A; Evans, Denis A.

In: Journal of Neurology Neurosurgery and Psychiatry, Vol. 69, No. 2, 08.2000, p. 172-177.

Research output: Contribution to journalArticle

Wilson, Robert S. ; Gilley, David W. ; Bennett, David A. ; Beckett, Laurel A ; Evans, Denis A. / Hallucinations, delusions, and cognitive decline in Alzheimer's disease. In: Journal of Neurology Neurosurgery and Psychiatry. 2000 ; Vol. 69, No. 2. pp. 172-177.
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